Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF2R | P11717 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.44 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.44 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.44 |
| ▸ | LGALS4 | P56470 | 1/20 | 0.44 |
| ▸ | SELE | P16581 | 1/20 | 0.43 |
| ▸ | FGF1 | P05230 | 1/20 | 0.43 |
| ▸ | FGF2 | P09038 | 1/20 | 0.43 |
| ▸ | VEGFA | P15692 | 1/20 | 0.43 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | AMY2A | P04746 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19480148 | 0.92 | IGF2R (0.46) | IGF2RMEN1KMT2AAMY1ALGALS8 | |
| SCHEMBL19480247 | 0.92 | IGF2R (0.46) | IGF2RMEN1KMT2AAMY1ALGALS8 | |
| SCHEMBL16587627 | 0.88 | AMY1A (0.47) | IGF2RAMY1ASELESTAT3PTPN1 | |
| SCHEMBL16869952 | 0.88 | AMY1A (0.47) | IGF2RAMY1ASELESTAT3PTPN1 | |
| SCHEMBL19480243 | 0.87 | IGF2R (0.42) | IGF2RMEN1KMT2AAMY1ALGALS3 | |
| SCHEMBL24239941 | 0.87 | FGF2 (0.40) | IGF2RAMY1AFGF2HPSEMAPT | |
| SCHEMBL22844793 | 0.87 | FGF2 (0.40) | IGF2RAMY1AFGF2HPSEMAPT | |
| SCHEMBL26032277 | 0.87 | AMY1A (0.54) | IGF2RMEN1KMT2AAMY1ALGALS8 | |
| SCHEMBL16587625 | 0.87 | SELE (0.48) | IGF2RMEN1KMT2AAMY1ASELE | |
| SCHEMBL27279098 | 0.86 | AMY1A (0.51) | IGF2RMEN1KMT2AAMY1ALGALS8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200163983-A1 | SAPONIN COMPOUND TARGETING PD-1 AND APPLICATION THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2020-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200163983-A1 | SAPONIN COMPOUND TARGETING PD-1 AND APPLICATION THEREOF | PDCD1, CD274, PDCD1LG2 | IGF2R 1923/4885MEN1 2041/4885KMT2A 3424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.