Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 8/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5615724 | 0.83 | LMNA (0.46) | ALDH1A1LMNAKDM4EMAPTMEN1 | |
| SCHEMBL4428990 | 0.82 | MAPT (0.48) | ALDH1A1MAPTMEN1KMT2APOLB | |
| SCHEMBL22816100 | 0.82 | NOTUM (0.56) | NOTUM | |
| SCHEMBL5598235 | 0.81 | MAPT (0.59) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL5130122 | 0.79 | ALDH1A1 (0.41) | ALDH1A1LMNAKDM4EMAPTMEN1 | |
| SCHEMBL24073901 | 0.79 | MAPT (0.57) | ALDH1A1LMNAKDM4EMAPTMEN1 | |
| SCHEMBL2712073 | 0.78 | SLC6A9 (0.50) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL5005578 | 0.78 | SIRT6 (0.61) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL27789 | 0.78 | MAPT (0.64) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL5609833 | 0.77 | LMNA (0.42) | ALDH1A1LMNAKDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020117877-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF USE | AQUINNAH PHARMACEUTICALS, INC. (US) | 2020-06-11 | — | — | WO | disclosed |
| WO-2020117877-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF USE | AQUINNAH PHARMACEUTICALS, INC. (US) | 2020-06-11 | — | — | WO | disclosed |