Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30046479 | 1.00 | SYK (0.39) | SYKKDM4EHSD17B10KCNH2NPC1 | |
| SCHEMBL30045875 | 0.89 | KCNH2 (0.35) | SYKKDM4EKCNH2MEN1KMT2A | |
| SCHEMBL22044745 | 0.89 | KCNH2 (0.35) | SYKKDM4EKCNH2MEN1KMT2A | |
| SCHEMBL25806736 | 0.89 | ALDH1A1 (0.36) | KDM4EKCNH2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21988960 | 0.88 | KMO (0.44) | KDM4EHSD17B10KCNH2MEN1KMT2A | |
| SCHEMBL22044746 | 0.86 | MEN1 (0.37) | KCNH2NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL30046458 | 0.83 | KCNH2 (0.44) | SYKKDM4EHSD17B10KCNH2NPC1 | |
| SCHEMBL22046559 | 0.83 | KCNH2 (0.44) | SYKKDM4EHSD17B10KCNH2NPC1 | |
| SCHEMBL22044747 | 0.83 | KCNH2 (0.44) | SYKKDM4EHSD17B10KCNH2NPC1 | |
| SCHEMBL22046557 | 0.81 | KCNH2 (0.35) | KDM4EKCNH2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230382892-A1 | Chemical Compounds | PFIZER INC. (US) | 2023-11-30 | — | — | US | disclosed |
| US-11702405-B2 | Chemical compounds | PFIZER INC. (US) | 2023-07-18 | — | — | US | disclosed |
| US-11014908-B2 | Chemical compounds | PFIZER INC. (US) | 2021-05-25 | — | — | US | disclosed |
| US-20200172512-A1 | Chemical Compounds | PFIZER INC. (US) | 2020-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200172512-A1 | Chemical Compounds | HBZ, HBB, HBS1L | SYK 1075/4885KDM4E 2745/4885HSD17B10 1652/4885 |
| US-11702405-B2 | Chemical compounds | HBZ, HBB, HBS1L | SYK 1075/4885KDM4E 2745/4885HSD17B10 1652/4885 |
| US-20230382892-A1 | Chemical Compounds | HBZ, HBB, HBS1L | SYK 1075/4885KDM4E 2745/4885HSD17B10 1652/4885 |
| US-11014908-B2 | Chemical compounds | HBZ, HBB, HBS1L | SYK 1075/4885KDM4E 2745/4885HSD17B10 1652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.