SCHEMBL220480

SCHEMBL220480

O=C(Nc1cc(Br)cc(-n2cccn2)c1)N(S)C(=O)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KAT6A Q92794 8/20 0.39
HDAC4 P56524 1/20 0.37
LMNA P02545 1/20 0.35
RXFP1 Q9HBX9 1/20 0.34
TP53 P04637 1/20 0.33
FGFR1 P11362 2/20 0.33
PTPN1 P18031 1/20 0.33
HRH3 Q9Y5N1 1/20 0.32
BRD4 O60885 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL220680 0.81 MEN1 (0.41) LMNATP53
SCHEMBL220479 0.78 EPHX1 (0.55) LMNA
SCHEMBL220188 0.76 MEN1 (0.37) LMNATP53
SCHEMBL222250 0.74 MEN1 (0.36) TP53
SCHEMBL221583 0.70 ADORA2A (0.35) LMNATP53FGFR1
SCHEMBL14859165 0.70 ALDH1A1 (0.51) TP53PTPN1
SCHEMBL222509 0.70 NPC1 (0.45)
SCHEMBL221584 0.69 LMNA (0.36) KAT6AHDAC4LMNAPTPN1
SCHEMBL220071 0.69 SMN1; SMN2 (0.37) TP53
SCHEMBL5713541 0.69 THRB (0.51) RXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8481544-B2 Antibacterial compositions BIOTA EUROPE LIMITED (GB) 2013-07-09 US disclosed
US-8389516-B2 Antibacterial compositions BIOTA EUROPE LIMITED (GB) 2013-03-05 US disclosed
EP-2034997-B1 ANTIBACTERIAL COMPOSITIONS BIOTA EUROPE LTD (GB) 2012-10-17 EP disclosed
US-20120004221-A1 Antibacterial Compositions BIOTA EUROPE LIMITED (GB) 2012-01-05 US disclosed
US-20110263590-A1 Antibacterial Compositions BIOTA EUROPE LIMITED (GB) 2011-10-27 US disclosed
US-7977340-B2 Antibacterial compositions PROLYSIS LTD. (GB) 2011-07-12 US disclosed
US-20090197877-A1 Antibacterial Compositions PROLYSIS LTD. (GB) 2009-08-06 US disclosed
EP-2034997-A1 ANTIBACTERIAL COMPOSITIONS Prolysis Limited (GB) 2009-03-18 EP disclosed
WO-2007148093-A1 ANTIBACTERIAL COMPOSITIONS PROLYSIS LTD. (GB) 2007-12-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120004221-A1 Antibacterial Compositions CYCS, COX6C, RPS6 KAT6A 195/4885HDAC4 3394/4885LMNA 3158/4885
US-20090197877-A1 Antibacterial Compositions CYCS, COX6C, INTS6 KAT6A 224/4885HDAC4 2421/4885LMNA 3994/4885
US-20110263590-A1 Antibacterial Compositions CYCS, COX6C, RPS6 KAT6A 198/4885HDAC4 3391/4885LMNA 3241/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.