Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 8/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | HTR1D | P28221 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | HTR1B | P28222 | 1/20 | 0.52 |
| ▸ | HTR1E | P28566 | 1/20 | 0.52 |
| ▸ | HTR1F | P30939 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172325 | 0.81 | CYP3A4 (0.60) | GHSRHTR6ALDH1A1MEN1KMT2A | |
| SCHEMBL2365378 | 0.81 | UTS2R (0.48) | HTR6ALDH1A1MEN1KMT2ADRD2 | |
| SCHEMBL6970959 | 0.78 | HTR6 (0.81) | GHSRHTR6ALDH1A1MEN1KMT2A | |
| SCHEMBL2303191 | 0.77 | HTR6 (0.50) | HTR6ALDH1A1MEN1KMT2ADRD2 | |
| SCHEMBL29048773 | 0.75 | LMNA (0.79) | ALDH1A1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL30532978 | 0.75 | LMNA (0.79) | ALDH1A1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL2170321 | 0.72 | CYP3A4 (0.59) | GHSRHTR6ALDH1A1MEN1KMT2A | |
| SCHEMBL2172090 | 0.71 | POLB (0.53) | ALDH1A1MEN1KMT2ACYP3A4LMNA | |
| SCHEMBL2170708 | 0.71 | HTR6 (0.63) | HTR6ALDH1A1MEN1KMT2ADRD2 | |
| SCHEMBL2171187 | 0.71 | GHSR (0.53) | GHSRHTR6ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346847-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | Suven Life Sciences Limited (IN) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010032258-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2010-03-25 | — | — | WO | disclosed |