Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 5/20 | 0.48 |
| ▸ | HTR6 | P50406 | 8/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR1E | P28566 | 1/20 | 0.45 |
| ▸ | HTR1F | P30939 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6117937 | 0.82 | CYP3A4 (0.50) | UTS2RHTR6CYP1A2CYP3A4HTR1A | |
| SCHEMBL2205372 | 0.81 | GHSR (0.52) | HTR6CYP1A2CYP3A4HTR1ACYP2D6 | |
| SCHEMBL2171526 | 0.80 | UTS2R (0.47) | UTS2RHTR6CYP1A2CYP3A4HTR1A | |
| SCHEMBL6977609 | 0.79 | HTR6 (0.72) | HTR6CYP1A2CYP3A4HTR1ACYP2D6 | |
| SCHEMBL6118762 | 0.73 | CYP3A4 (0.50) | UTS2RHTR6CYP3A4HTR1AHTR2A | |
| SCHEMBL2169541 | 0.72 | CYP3A4 (0.52) | UTS2RHTR6CYP3A4HTR1AHTR7 | |
| SCHEMBL6118587 | 0.71 | CYP3A4 (0.51) | UTS2RHTR6CYP3A4HTR1ACYP2D6 | |
| SCHEMBL5210116 | 0.70 | HTR1F (0.53) | HTR6HTR1FBRD4TRIM24TP53 | |
| SCHEMBL2171141 | 0.69 | HTR6 (0.49) | UTS2RHTR6BRD4CREBBPTP53 | |
| SCHEMBL28750145 | 0.68 | PGR (0.56) | TP53ALDH1A1LMNAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346847-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | Suven Life Sciences Limited (IN) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010032258-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2010-03-25 | — | — | WO | disclosed |