Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2170217 | 0.81 | SMN1; SMN2 (0.49) | HTR6DRD2HTR2AHTR2CDRD3 | |
| SCHEMBL2205372 | 0.77 | GHSR (0.52) | HTR6DRD2HTR2AHTR2CDRD3 | |
| SCHEMBL2170110 | 0.74 | L3MBTL1 (0.52) | HTR6HTR2AHTR2CDRD3SMN1; SMN2 | |
| SCHEMBL6117477 | 0.74 | TP53 (0.47) | HTR6SMN1; SMN2TP53PKMCYP3A4 | |
| SCHEMBL5871087 | 0.73 | HTR1A (0.64) | HTR6DRD2HTR2AHTR2CDRD3 | |
| SCHEMBL2169741 | 0.73 | HSD17B3 (0.49) | HTR6DRD2HTR2AHTR2CDRD3 | |
| SCHEMBL4873695 | 0.73 | ALDH1A1 (0.58) | HTR2AHTR2CSMN1; SMN2TP53PKM | |
| SCHEMBL2170321 | 0.72 | CYP3A4 (0.59) | HTR6DRD2HTR2AHTR2CDRD3 | |
| SCHEMBL7574073 | 0.71 | CA1 (0.62) | SMN1; SMN2TP53PKMCYP3A4CYP2C9 | |
| SCHEMBL5212060 | 0.71 | HTR1F (0.68) | SMN1; SMN2CYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346847-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | Suven Life Sciences Limited (IN) | 2011-07-27 | — | — | EP | claimed |
| WO-2010032258-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2010-03-25 | — | — | WO | claimed |