Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLH | Q9Y253 | 6/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | GAA | P10253 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | MMP1 | P03956 | 1/20 | 0.58 |
| ▸ | APEX1 | P27695 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.52 |
| ▸ | TUBB | P07437 | 1/20 | 0.52 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.52 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.52 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25859147 | 0.88 | POLH (0.56) | POLHKDM4EGAAPOLBMAPT | |
| SCHEMBL22549001 | 0.81 | POLH (0.74) | POLHKDM4EGAAPOLBMAPT | |
| SCHEMBL19490598 | 0.81 | POLH (0.70) | POLHKDM4EGAAPOLBMAPT | |
| SCHEMBL28041625 | 0.80 | POLH (0.76) | POLHKDM4EGAAPOLBMAPT | |
| SCHEMBL24092242 | 0.77 | POLH (0.70) | POLHKDM4EGAAPOLBMAPT | |
| SCHEMBL12474049 | 0.76 | KDM4E (0.68) | KDM4EGAAPOLBMAPTAPEX1 | |
| SCHEMBL14384281 | 0.76 | CYP3A4 (0.55) | POLHKDM4EGAAPOLBMAPT | |
| SCHEMBL17620267 | 0.76 | POLH (0.78) | POLHKDM4EGAAPOLBMAPT | |
| Quercetin SCHEMBL20483106 | 0.75 | MEN1 (0.79) | POLHKDM4EGAAPOLBMAPT | |
| SCHEMBL4650695 | 0.75 | KDM4E (0.70) | KDM4EGAAPOLBMAPTAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11872241-B2 | Compositions and methods for reducing major thrombotic events in cancer patients | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2024-01-16 | — | — | US | disclosed |
| US-20200171064-A1 | COMPOSITIONS AND METHODS FOR REDUCING MAJOR THROMBOTIC EVENTS IN CANCER PATIENTS | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. | 2020-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200171064-A1 | COMPOSITIONS AND METHODS FOR REDUCING MAJOR THROMBOTIC EVENTS IN CANCER PATIENTS | SELP, SELE, SELPLG | POLH 2241/4885KDM4E 3842/4885GAA 2808/4885 |
| US-11872241-B2 | Compositions and methods for reducing major thrombotic events in cancer patients | SELP, SELE, SELPLG | POLH 2241/4885KDM4E 3842/4885GAA 2808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.