Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.49 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.49 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.49 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MERTK | Q12866 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22065392 | 0.88 | ALDH1A1 (0.52) | ALDH1A1AKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL6564098 | 0.85 | AKR1C3 (0.47) | ALDH1A1AKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL22064872 | 0.83 | ALDH1A1 (0.40) | ALDH1A1AKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL269614 | 0.83 | AKR1C3 (0.63) | ALDH1A1AKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL12326834 | 0.83 | ALDH1A1 (0.53) | ALDH1A1AKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL30580504 | 0.83 | AKR1C3 (0.63) | ALDH1A1AKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL13564438 | 0.82 | HSPB1 (0.48) | ALDH1A1LMNASMN1; SMN2MERTKMAPT | |
| SCHEMBL4946199 | 0.81 | AKR1C3 (0.51) | ALDH1A1AKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL268414 | 0.81 | TDP1 (0.62) | ALDH1A1AKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL404510 | 0.81 | MAPT (0.51) | ALDH1A1AKR1C3AKR1C2AKR1B10AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200181101-A1 | BENZAMIDE INHIBITORS OF BACTERIAL LIPOPROTEIN SIGNAL PEPTIDASE | SCRIPPS RESEARCH INST (US) | 2020-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200181101-A1 | BENZAMIDE INHIBITORS OF BACTERIAL LIPOPROTEIN SIGNAL PEPTIDASE | LPL, LIPE, LYPLA2 | ALDH1A1 3104/4885AKR1C3 4608/4885AKR1C2 4228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.