SCHEMBL22068581

SCHEMBL22068581

C1=CCCC(c2ccc(-c3ccc(-c4ccccc4)nc3)cn2)=C1

nearest known ligand 0.44

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HPGDS O60760 2/20 0.44
CHRNB2 P17787 4/20 0.40
CHRNA3 P32297 2/20 0.40
CHRNA7 P36544 3/20 0.39
CHRNA4 P43681 3/20 0.39
CHRNB4 P30926 1/20 0.39
LDHA P00338 1/20 0.38
HSD17B1 P14061 1/20 0.37
HSD17B2 P37059 1/20 0.37
CYP11B1 P15538 4/20 0.35
CYP11B2 P19099 4/20 0.35
BAZ2B Q9UIF8 1/20 0.34
DGAT1 O75907 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21202863 0.85 HPGDS (0.36) HPGDSCHRNB2CHRNA3CHRNA7CHRNA4
SCHEMBL18015551 0.85 HPGDS (0.36) HPGDSCHRNB2CHRNA3CHRNA7CHRNA4
SCHEMBL19526639 0.77 ASIC3 (0.45)
SCHEMBL787585 0.76 ALDH1A1 (0.36) CHRNA3CHRNB4
SCHEMBL12973036 0.76 HPGDS (0.60) HPGDSCHRNB2CHRNA3CHRNA7CHRNA4
SCHEMBL21003482 0.76 ASIC3 (0.44)
SCHEMBL18792381 0.74 LDHA (0.47) LDHACYP11B1CYP11B2DGAT1
SCHEMBL18849413 0.74 CCR1 (0.50)
SCHEMBL19818395 0.74 CASP3 (0.34)
SCHEMBL25118611 0.74 HPGDS (0.58) HPGDSCHRNB2CHRNA3LDHAHSD17B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3247771-B1 PYRIDINES AND DERIVATIVES THEREOF AS COMPONENTS FOR USE IN OPTOELECTRONIC COMPONENTS CYNORA GMBH (DE) 2020-06-10 EP disclosed