SCHEMBL22069578

SCHEMBL22069578

O=[N+]([O-])c1ccc(Oc2ccccc2Cl)c(Cl)c1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.63
KMT2A Q03164 5/20 0.63
MEN1 O00255 4/20 0.63
PDE7A Q13946 2/20 0.61
MAPT P10636 5/20 0.58
ALDH1A1 P00352 4/20 0.58
SMN1; SMN2 Q16637 3/20 0.58
LMNA P02545 3/20 0.58
NPC1 O15118 1/20 0.58
CYP1A2 P05177 1/20 0.58
CYP3A4 P08684 1/20 0.58
CYP2D6 P10635 1/20 0.58
CYP2C9 P11712 1/20 0.58
CYP2C19 P33261 1/20 0.58
RAB9A P51151 1/20 0.58
NPSR1 Q6W5P4 1/20 0.58
TBXA2R P21731 2/20 0.55
HSD17B10 Q99714 1/20 0.55
HSPB1 P04792 1/20 0.54
MAPK1 P28482 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30098850 1.00 HPGD (0.63) HPGDKMT2AMEN1PDE7AMAPT
SCHEMBL11511746 0.91 PDE7A (0.71) HPGDKMT2AMEN1PDE7AMAPT
SCHEMBL22069554 0.89 KMT2A (0.62) HPGDKMT2AMEN1PDE7AMAPT
SCHEMBL22114316 0.88 HPGD (0.56) HPGDKMT2AMEN1PDE7AMAPT
SCHEMBL4029870 0.85 PDE7A (0.73) HPGDKMT2AMEN1PDE7AMAPT
SCHEMBL6237528 0.85 KMT2A (0.65) HPGDKMT2AMEN1PDE7AMAPT
SCHEMBL4965383 0.85 PDE7A (0.63) HPGDKMT2AMEN1PDE7AMAPT
SCHEMBL10962765 0.84 MAPT (0.56) HPGDKMT2AMEN1PDE7AMAPT
SCHEMBL4697145 0.84 KMT2A (0.54) HPGDKMT2AMEN1PDE7AMAPT
SCHEMBL1471670 0.84 CYP1A2 (0.53) HPGDKMT2AMEN1PDE7AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4097111-B9 PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2025-10-29 EP disclosed
US-12415815-B2 Pyrido[2,3-e]oxazine derivatives as agricultural chemicals GLOBACHEM NV (BE) 2025-09-16 US disclosed
EP-4097111-B1 PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2025-07-23 EP disclosed
CN-115427415-B Pyrido [2,3-E ] oxazine derivatives as agrochemicals 环球化学股份有限公司 2024-07-12 CN disclosed
US-20230151023-A1 PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2023-05-18 US disclosed
US-20230151023-A1 PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2023-05-18 US disclosed
EP-4097111-A1 PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS Globachem NV (BE) 2022-12-07 EP disclosed
CN-115427415-A Pyrido [2,3-E ] oxazine derivatives for use as agrochemicals 环球化学股份有限公司 2022-12-02 CN disclosed
WO-2021151919-A1 PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2021-08-05 WO disclosed
WO-2021151919-A1 PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2021-08-05 WO disclosed
EP-3666769-A1 NOVEL CASPASE INHIBITORS RIJKSUNIVERSITEIT GRONINGEN (NL) 2020-06-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230151023-A1 PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS PNPO, HPD, PDXK HPGD 488/4885KMT2A 3565/4885MEN1 1703/4885
US-12415815-B2 Pyrido[2,3-e]oxazine derivatives as agricultural chemicals PNPO, HPD, PDXK HPGD 488/4885KMT2A 3565/4885MEN1 1703/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.