Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.49 |
| ▸ | PARG | Q86W56 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RNF4 | P78317 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | FNTA | P49354 | 1/20 | 0.45 |
| ▸ | FNTB | P49356 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | PNLIP | P16233 | 2/20 | 0.45 |
| ▸ | GSTO1 | P78417 | 2/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22069580 | 0.87 | PNLIP (0.54) | METPARGMITFALDH1A1POLB | |
| SCHEMBL22069738 | 0.87 | HTR2A (0.49) | METPARGALDH1A1SCN9ACYP3A4 | |
| SCHEMBL22069703 | 0.85 | MET (0.48) | METPARGMITFALDH1A1POLB | |
| SCHEMBL22069611 | 0.84 | P2RX4 (0.57) | METPARGMITFALDH1A1POLB | |
| SCHEMBL22069696 | 0.84 | RNF4 (0.51) | METPARGMITFALDH1A1POLB | |
| SCHEMBL22069558 | 0.83 | FFAR1 (0.50) | METPARGMITFALDH1A1POLB | |
| SCHEMBL22069737 | 0.81 | FFAR1 (0.53) | METMITFALDH1A1POLBMAPK1 | |
| SCHEMBL22069574 | 0.81 | ALDH1A1 (0.48) | METPARGMITFALDH1A1POLB | |
| SCHEMBL22114135 | 0.81 | P2RX4 (0.52) | METMITFALDH1A1POLBMAPK1 | |
| SCHEMBL4003878 | 0.78 | CYP3A4 (0.71) | ALDH1A1HTTCYP3A4GSTO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3666769-A1 | NOVEL CASPASE INHIBITORS | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2020-06-17 | — | — | EP | disclosed |
| EP-3666769-A1 | NOVEL CASPASE INHIBITORS | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2020-06-17 | — | — | EP | disclosed |