Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 3/20 | 0.40 |
| ▸ | KLK1 | P06870 | 3/20 | 0.40 |
| ▸ | KLK6 | Q92876 | 3/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.39 |
| ▸ | GLRB | P48167 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.38 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5963870 | 0.85 | LMNA (0.43) | NR1H4ALDH1A1CDC25BCASP6RCE1 | |
| SCHEMBL29338525 | 0.82 | ALDH1A1 (0.46) | ALDH1A1CDC25BCASP6RCE1KLKB1 | |
| SCHEMBL901518 | 0.82 | NR1H4 (0.41) | NR1H4ALDH1A1CDC25BCASP6RCE1 | |
| SCHEMBL29601963 | 0.79 | NR1H4 (0.41) | NR1H4ALDH1A1CDC25BCASP6RCE1 | |
| SCHEMBL6451619 | 0.79 | ALDH1A1 (0.52) | ALDH1A1CDC25BCASP6RCE1KLKB1 | |
| SCHEMBL16823553 | 0.78 | PPARA (0.41) | NR1H4ALDH1A1CASP6EPHX2GLRA3 | |
| SCHEMBL1146167 | 0.78 | NR1H4 (0.50) | NR1H4ALDH1A1CDC25BCASP6RCE1 | |
| Hydrochloric Acid SCHEMBL479729 | 0.76 | NR1H4 (0.49) | NR1H4ALDH1A1CDC25BCASP6RCE1 | |
| SCHEMBL20267768 | 0.76 | GABRP (0.46) | ALDH1A1CDC25BCASP6RCE1KLKB1 | |
| SCHEMBL1018101 | 0.76 | SLC7A5 (0.40) | NR1H4ALDH1A1CDC25BCASP6RCE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110230468-A1 | FUSED HETEROCYCLIC COMPOUNDS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2011-09-22 | — | — | US | disclosed |
| US-7981881-B2 | Fused heterocyclic compounds and use thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-07-19 | — | — | US | disclosed |
| US-7384937-B2 | Fused heterocyclic compounds and use thereof | BRISTOL-MYERS SQUIBB CO. (US) | 2008-06-10 | — | — | US | disclosed |
| US-20040142945-A1 | Fused heterocyclic compounds and use thereof | BRISTOL-MYERS SQUIBB COMPANY | 2004-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230468-A1 | FUSED HETEROCYCLIC COMPOUNDS AND USES THEREOF | MCL1, FPR1, LTC4S | NR1H4 695/4885ALDH1A1 522/4885CDC25B 1154/4885 |
| US-20040142945-A1 | Fused heterocyclic compounds and use thereof | MCL1, NFATC1, BCR | NR1H4 536/4885ALDH1A1 353/4885CDC25B 999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.