Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.62 |
| ▸ | MMP9 | P14780 | 4/20 | 0.62 |
| ▸ | MMP8 | P22894 | 4/20 | 0.62 |
| ▸ | MMP12 | P39900 | 4/20 | 0.62 |
| ▸ | MMP13 | P45452 | 4/20 | 0.62 |
| ▸ | MMP14 | P50281 | 4/20 | 0.62 |
| ▸ | MMP16 | P51512 | 4/20 | 0.62 |
| ▸ | MMP1 | P03956 | 2/20 | 0.62 |
| ▸ | MMP3 | P08254 | 3/20 | 0.54 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.43 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15303318 | 0.85 | MMP2 (0.62) | MMP2MMP9MMP8MMP12MMP13 | |
| SCHEMBL7351490 | 0.84 | MMP2 (0.60) | MMP2MMP9MMP8MMP12MMP13 | |
| SCHEMBL16896758 | 0.84 | MMP2 (0.45) | MMP2MMP9MMP8MMP12MMP13 | |
| SCHEMBL31027970 | 0.83 | MMP2 (0.49) | MMP2MMP9MMP8MMP12MMP13 | |
| SCHEMBL30153520 | 0.83 | MMP2 (0.49) | MMP2MMP9MMP8MMP12MMP13 | |
| SCHEMBL9228368 | 0.82 | MMP2 (0.82) | MMP2MMP9MMP8MMP12MMP13 | |
| Hydrochloric Acid SCHEMBL28765687 | 0.82 | MMP2 (0.48) | MMP2MMP9MMP8MMP12MMP13 | |
| SCHEMBL2204495 | 0.80 | PTGS2 (0.56) | MMP2MMP9MMP8MMP12MMP13 | |
| SCHEMBL28748849 | 0.79 | HTR2A (0.49) | MMP2MMP9MMP8MMP12MMP13 | |
| SCHEMBL1106525 | 0.78 | L3MBTL1 (0.52) | MMP2MMP9MMP8MMP12MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791268-B2 | Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof for treating pain and other conditions | GRUENENTHAL GMBH (DE) | 2014-07-29 | — | — | US | disclosed |
| US-8642775-B2 | Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof for treating pain and other conditions | GRUENENTHAL GMBH (DE) | 2014-02-04 | — | — | US | disclosed |
| US-20110184020-A1 | Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process For Making Them, and Use Thereof For Treating Pain and Other Conditions | GRUENENTHAL GMBH (DE) | 2011-07-28 | — | — | US | disclosed |
| US-20080262039-A1 | Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process For Making Them, and Use Thereof For Treating Pain and Other Conditions | GRUENENTHAL GMBH (DE) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262039-A1 | Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process For Making Them, and Use Thereof For Treating Pain and Other Conditions | TRPV1, TRPV2, TRPV3 | MMP2 3298/4885MMP9 2860/4885MMP8 1240/4885 |
| US-20110184020-A1 | Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process For Making Them, and Use Thereof For Treating Pain and Other Conditions | TRPV1, TRPV2, TRPV3 | MMP2 3298/4885MMP9 2860/4885MMP8 1240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.