Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.34 |
| ▸ | PLK1 | P53350 | 4/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22089989 | 0.86 | PTK2 (0.39) | MAPK1ALDH1A1PTK2PLK1FGFR1 | |
| SCHEMBL22090143 | 0.84 | MEN1 (0.35) | MAPK1ALDH1A1CDK2CDK1GSK3A | |
| SCHEMBL22090032 | 0.70 | KCNMA1 (0.44) | ALDH1A1CDK2LCKCDK1GSK3B | |
| SCHEMBL21198864 | 0.63 | MAPT (0.44) | ALDH1A1AGTR1EGFRCHEK1MAPK8 | |
| SCHEMBL3559372 | 0.62 | ALDH1A1 (0.44) | MAPK1ALDH1A1HTTGAA | |
| SCHEMBL22120118 | 0.61 | GRIA1 (0.42) | ALDH1A1HTT | |
| SCHEMBL30142224 | 0.61 | GRIA1 (0.42) | ALDH1A1HTT | |
| SCHEMBL17372668 | 0.61 | USP8 (0.44) | ALDH1A1AGTR1HTTLMNA | |
| SCHEMBL3173410 | 0.60 | HTT (0.45) | ALDH1A1EGFRERBB2CHEK1HTT | |
| SCHEMBL23314963 | 0.60 | FGFR4 (0.52) | MAPK1ALDH1A1FGFR1FGFR3FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020119606-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR | GUANGDONG NEWOPP BIOPHARMACEUTICALS CO., LTD. (CN) | 2020-06-18 | — | — | WO | disclosed |