SCHEMBL2209641

SCHEMBL2209641

CCC(CC)COc1cccc(Br)c1

nearest known ligand 0.54

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MAOB P27338 8/20 0.51
KDM4E B2RXH2 4/20 0.48
HSD17B10 Q99714 1/20 0.44
ALDH1A1 P00352 4/20 0.44
LMNA P02545 1/20 0.44
KMT2A Q03164 2/20 0.44
HTT P42858 1/20 0.43
RAB9A P51151 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
SOD1 P00441 1/20 0.43
MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26987629 0.88 MAOB (0.44) MAOBKDM4EHSD17B10ALDH1A1LMNA
SCHEMBL17138204 0.87 TSHR (0.49) KDM4ELMNA
SCHEMBL2206785 0.86 MAOB (0.53) MAOBKDM4EHSD17B10ALDH1A1LMNA
SCHEMBL4970580 0.84 MAOB (0.50) MAOBKDM4EHSD17B10ALDH1A1LMNA
SCHEMBL14027336 0.83 ALDH1A1 (0.54) MAOBKDM4EHSD17B10ALDH1A1LMNA
SCHEMBL4349792 0.81 MAOB (0.55) MAOBKDM4EHSD17B10ALDH1A1LMNA
SCHEMBL26674845 0.81 MAOB (0.47) MAOBKDM4EHSD17B10ALDH1A1LMNA
Ammonia Solution, Strong SCHEMBL3967918 0.80 TP53 (0.52) KDM4EALDH1A1LMNAHTTL3MBTL1
SCHEMBL29421566 0.79 MAOB (0.49) MAOBKDM4EHSD17B10ALDH1A1LMNA
SCHEMBL102555 0.79 MAOB (0.49) MAOBKDM4EHSD17B10ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12029708-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2024-07-09 US disclosed
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2023-07-13 US disclosed
US-11446261-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2022-09-20 US disclosed
US-20210077427-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2021-03-18 US disclosed
US-10639286-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2020-05-05 US disclosed
US-20190183816-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2019-06-20 US disclosed
US-10188615-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2019-01-29 US disclosed
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2018-06-28 US disclosed
EP-3210966-A1 ALKOXYPHENYLPROPYLAMINES FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION Acucela, Inc. (US) 2017-08-30 EP disclosed
US-9737496-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2017-08-22 US disclosed
US-8829244-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2014-09-09 US disclosed
US-20130197096-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA, INC. (US) 2013-08-01 US disclosed
US-20120214852-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-08-23 US disclosed
US-20120129894-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-24 US disclosed
US-20120122938-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-17 US disclosed
US-7982071-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2011-07-19 US disclosed
CN-101889017-A Alkoxy compounds for the treatment of diseases ACUCELA INC 2010-11-17 CN disclosed
US-20090326074-A1 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2009-12-31 US disclosed
EP-2091955-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT Acucela, Inc. (US) 2009-08-26 EP disclosed
WO-2009045479-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. (US) 2009-04-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12029708-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER MAOB 318/4885KDM4E 2349/4885HSD17B10 178/4885
US-20120122938-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER MAOB 318/4885KDM4E 2349/4885HSD17B10 178/4885
US-20210077427-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER MAOB 318/4885KDM4E 2349/4885HSD17B10 178/4885
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER MAOB 332/4885KDM4E 2227/4885HSD17B10 167/4885
US-20190183816-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER MAOB 318/4885KDM4E 2349/4885HSD17B10 178/4885
US-20130197096-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER MAOB 318/4885KDM4E 2349/4885HSD17B10 178/4885
US-11446261-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER MAOB 318/4885KDM4E 2349/4885HSD17B10 178/4885
US-20120214852-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER MAOB 318/4885KDM4E 2349/4885HSD17B10 178/4885
US-20090326074-A1 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER MAOB 318/4885KDM4E 2349/4885HSD17B10 178/4885
US-10188615-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER MAOB 318/4885KDM4E 2349/4885HSD17B10 178/4885
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER MAOB 318/4885KDM4E 2349/4885HSD17B10 178/4885
US-20120129894-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER MAOB 318/4885KDM4E 2349/4885HSD17B10 178/4885
US-10639286-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER MAOB 318/4885KDM4E 2349/4885HSD17B10 178/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.