SCHEMBL22100303

SCHEMBL22100303

CNc1ccc(C=C2C(=O)NC(=O)NC2=O)cc1

nearest known ligand 0.61

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ METAP1 P53582 6/20 0.61
▸ MAPT P10636 7/20 0.57
▸ APP P05067 1/20 0.57
▸ CA12 O43570 1/20 0.54
▸ CA1 P00915 1/20 0.54
▸ CA2 P00918 1/20 0.54
▸ CA7 P43166 1/20 0.54
▸ CA9 Q16790 1/20 0.54
▸ ALDH1A1 P00352 5/20 0.50
▸ KDM4E B2RXH2 2/20 0.50
▸ GAA P10253 1/20 0.50
▸ POLB P06746 2/20 0.49
▸ KMT2A Q03164 2/20 0.48
▸ MEN1 O00255 1/20 0.48
▸ L3MBTL1 Q9Y468 1/20 0.47
▸ PPARG P37231 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4428107 0.84 METAP1 (0.80) METAP1MAPTCA12CA1CA2
SCHEMBL28680183 0.79 METAP1 (0.67) METAP1MAPTCA12CA1CA2
SCHEMBL14033557 0.79 METAP1 (0.71) METAP1MAPTCA12CA1CA2
SCHEMBL13039183 0.78 APP (0.67) MAPTAPPALDH1A1KMT2AMEN1
SCHEMBL31406586 0.76 GSK3B (0.70) METAP1MAPTCA12CA1CA2
SCHEMBL21779711 0.76 METAP1 (0.67) METAP1MAPTCA12CA1CA2
SCHEMBL8083180 0.76 METAP1 (0.67) METAP1MAPTCA12CA1CA2
SCHEMBL16543019 0.76 METAP1 (1.00) METAP1MAPTCA12CA1CA2
SCHEMBL13848414 0.76 METAP1 (1.00) METAP1MAPTCA12CA1CA2
SCHEMBL4096609 0.75 METAP1 (1.00) METAP1MAPTAPPCA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12319661-B2 Polycyclic compound EUTEC NEW MATERIALS TECHNOLOGY (SUZHOU) CO., LTD. (CN) 2025-06-03 — — US disclosed
CN-115745970-B Polycyclic compound, preparation method and membrane 江苏裕事达新材料科技有限责任公司 2024-12-13 — — CN disclosed
CN-111285853-B Polycyclic compound 江苏裕事达新材料科技有限责任公司 2023-07-28 — — CN disclosed
CN-115745970-A Polycyclic compound, preparation method and film 江苏裕事达新材料科技有限责任公司 2023-03-07 — — CN disclosed
US-20220017474-A1 Novel Polycyclic Compound EUTEC NEW MATERIALS TECHNOLOGY (SUZHOU) CO., LTD. (CN) 2022-01-20 — — US disclosed
EP-3896067-A1 NOVEL POLYCYCLIC COMPOUND Eutec New Materials Technology (Suzhou) Co., Ltd (CN) 2021-10-20 — — EP disclosed
WO-2020118933-A1 NOVEL POLYCYCLIC COMPOUND 优缔新材料科技(苏州)有限公司 2020-06-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12319661-B2 Polycyclic compound CUTA, CDH1, DSG1 METAP1 4667/4885MAPT 187/4885APP 667/4885
US-20220017474-A1 Novel Polycyclic Compound CUTA, DSG1, UACA METAP1 4754/4885MAPT 295/4885APP 1095/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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