Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 8/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22100766 | 0.85 | TRPM8 (0.55) | TRPM8ALDH1A1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL22100703 | 0.70 | TRPM8 (0.75) | TRPM8ALDH1A1KDM4EMAPT | |
| SCHEMBL18569422 | 0.66 | KDM4E (0.72) | TRPM8ALDH1A1KDM4EMEN1NPC1 | |
| SCHEMBL18763039 | 0.66 | TRPM8 (0.67) | TRPM8ALDH1A1KDM4EMEN1NPC1 | |
| SCHEMBL5592456 | 0.65 | KDM4E (0.58) | TRPM8ALDH1A1KDM4EMEN1NPC1 | |
| SCHEMBL22100747 | 0.65 | TRPM8 (0.54) | TRPM8ALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL19314195 | 0.65 | GABRA1 (0.38) | — | |
| SCHEMBL10271037 | 0.65 | TRPM8 (1.00) | TRPM8ALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL22100808 | 0.65 | TRPM8 (1.00) | TRPM8ALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL31425727 | 0.65 | KDM4E (0.57) | TRPM8ALDH1A1KDM4EMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501761-B1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2020-06-17 | — | — | EP | disclosed |