Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.40 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11143781 | 0.77 | SRD5A2 (0.60) | RXRAMRGPRX4SRD5A2TSHRNR1H4 | |
| SCHEMBL27561164 | 0.76 | ALDH1A1 (0.59) | RXRAMRGPRX4SRD5A2TSHRNR1H4 | |
| SCHEMBL20844692 | 0.75 | FFAR1 (0.49) | RXRAMRGPRX4FFAR1RXRBRXRG | |
| SCHEMBL6493687 | 0.75 | TSHR (0.56) | RXRAMRGPRX4SRD5A2TSHRTAS2R14 | |
| SCHEMBL27986872 | 0.75 | TSHR (0.69) | RXRAFFAR1SRD5A2TSHRTAS2R14 | |
| SCHEMBL27555758 | 0.75 | FFAR1 (0.49) | RXRAMRGPRX4FFAR1SRD5A2TAS2R14 | |
| SCHEMBL2039607 | 0.75 | SLC22A12 (0.53) | RXRAMRGPRX4ARRXRBKDM4C | |
| SCHEMBL21386312 | 0.74 | SAE1 (0.54) | TSHRALDH1A1SAE1UBA2MEN1 | |
| SCHEMBL23349027 | 0.73 | FFAR1 (0.43) | MRGPRX4FFAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL11297291 | 0.73 | TAS2R14 (0.55) | ARFFAR1TAS2R14ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339147-B2 | Lactam compound as FXR receptor agonist | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD. (CN) | 2022-05-24 | — | — | US | disclosed |
| US-20200190074-A1 | LACTAM COMPOUND AS FXR RECEPTOR AGONIST | MEDSHINE DISCOVERY INC. (CN) | 2020-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11339147-B2 | Lactam compound as FXR receptor agonist | NR1H4, GPBAR1, SLC10A1 | RXRA 389/4885MRGPRX4 265/4885AR 805/4885 |
| US-20200190074-A1 | LACTAM COMPOUND AS FXR RECEPTOR AGONIST | NR1H4, GPBAR1, SLC10A1 | RXRA 389/4885MRGPRX4 265/4885AR 805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.