Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | RXRA | P19793 | 2/20 | 0.55 |
| ▸ | LDHA | P00338 | 3/20 | 0.51 |
| ▸ | LDHB | P07195 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.48 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | RXRG | P48443 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11143781 | 0.88 | SRD5A2 (0.60) | TSHRRXRARXRBRXRGALDH1A1 | |
| SCHEMBL27561164 | 0.87 | ALDH1A1 (0.59) | TSHRRXRARXRBALDH1A1MRGPRX4 | |
| SCHEMBL27510579 | 0.86 | TSHR (0.56) | TSHRRXRALDHALDHBLMNA | |
| SCHEMBL14312211 | 0.85 | DAO (0.47) | TSHRTAS2R14ALDH1A1MRGPRX4 | |
| SCHEMBL12117445 | 0.84 | ALDH1A1 (0.49) | RXRALDHALDHBLMNAALDH1A1 | |
| SCHEMBL31307947 | 0.84 | TSHR (0.61) | TSHRLMNAPTPN1PTPN2PTPN6 | |
| SCHEMBL11152749 | 0.83 | RXRA (0.49) | TSHRRXRALMNAALDH1A1MRGPRX4 | |
| SCHEMBL27986872 | 0.82 | TSHR (0.69) | TSHRRXRALMNATAS2R14RXRB | |
| SCHEMBL6772376 | 0.82 | TSHR (0.69) | TSHRLMNAPTPN1PTPN2PTPN6 | |
| SCHEMBL6943754 | 0.82 | PTPN1 (0.56) | RXRALDHALDHBLMNAPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492582-B2 | N-acyl anthranilic acid derivative or salt thereof | TOYAMA CHEMICAL CO., LTD. (JP) | 2013-07-23 | — | — | US | disclosed |
| US-20110275797-A1 | N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF | TOYAMA CHEMICAL CO., LTD. (JP) | 2011-11-10 | — | — | US | disclosed |
| US-6919335-B2 | Administering a therapeutically effective amount of a heterocyclic compound to the patient for the treatment of inosine monophosphate dehydrogenase associated disorders, such as allograft rejection | BRISTOL-MYERS SQUIBB CO. (US) | 2005-07-19 | — | — | US | disclosed |
| CN-1206212-C | Tri-substd. phenyl derivs. and analogues | ASTRAZENECA AB (SE) | 2005-06-15 | — | — | CN | disclosed |
| CN-1402703-A | Tri-substd. phenyl derivs. and analogues | ASTRAZENECA AB (SE) | 2003-03-12 | — | — | CN | disclosed |
| EP-1276739-A2 | HETEROCYCLES THAT ARE INHIBITORS OF IMPDH ENZYME | Bristol-Myers Squibb Company (US) | 2003-01-22 | — | — | EP | disclosed |
| US-20020040022-A1 | Heterocycles that are inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB COMPANY | 2002-04-04 | — | — | US | disclosed |
| WO-2001081340-A2 | HETEROCYCLES THAT ARE INHIBITORS OF IMPDH ENZYME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020040022-A1 | Heterocycles that are inhibitors of IMPDH enzyme | XDH, IMPDH1, IMPDH2 | TSHR 3496/4885RXRA 2438/4885LDHA 1820/4885 |
| US-20110275797-A1 | N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF | COL14A1, COL2A1, COL1A1 | TSHR 3928/4885RXRA 647/4885LDHA 1395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.