Citicoline

Citicoline

SCHEMBL221081

C[N+](C)(C)CCOP(=O)([O-])OP(=O)(O)OC[C@H]1O[C@@H](n2ccc(N)nc2=O)[C@H](O)[C@@H]1O

nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.73
GLA P06280 1/20 0.73
P2RY2 P41231 5/20 0.63
ST6GAL1 P15907 9/20 0.59
P2RY6 Q15077 4/20 0.56
P2RY4 P51582 2/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citicoline SCHEMBL31554836 1.00 TSHR (0.73) TSHRGLAP2RY2ST6GAL1P2RY6
Citicoline SCHEMBL50799 1.00 TSHR (0.73) TSHRGLAP2RY2ST6GAL1P2RY6
Citicoline SCHEMBL31413926 1.00 TSHR (0.73) TSHRGLAP2RY2ST6GAL1P2RY6
Citicoline SCHEMBL19347200 0.99 TSHR (0.72) TSHRGLAP2RY2ST6GAL1P2RY6
Citicoline SCHEMBL21906414 0.98 TSHR (0.70) TSHRGLAP2RY2ST6GAL1P2RY6
Citicoline SCHEMBL25411862 0.97 TSHR (0.76) TSHRGLAP2RY2ST6GAL1P2RY6
Citicoline SCHEMBL4311534 0.97 TSHR (0.76) TSHRGLAP2RY2ST6GAL1P2RY6
Citicoline SCHEMBL667104 0.93 TSHR (0.84) TSHRGLAP2RY2ST6GAL1P2RY6
Citicoline SCHEMBL14235352 0.93 P2RY2 (0.70) TSHRGLAP2RY2ST6GAL1P2RY6
Citicoline SCHEMBL13933086 0.93 P2RY2 (0.70) TSHRGLAP2RY2ST6GAL1P2RY6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2607 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122028930-A Recovery of TIM4 in liver macrophages for the treatment of nonalcoholic steatohepatitis (NASH) 纽约市哥伦比亚大学理事会 2026-05-12 CN claimed
US-20250376690-A1 RECOMBINANT ENGINEERED STRAIN FOR DE NOVO SYNTHESIS OF CDP-CHOLINE USING GLUCOSE AS SUBSTRATE AND ITS PREPARATION METHOD AND APPLICATION SHANDONG JINCHENG BIO PHARMACEUTICAL CO LTD (CN) 2025-12-11 US claimed
CN-120189509-A Novel target for treating metabolic-related fatty liver disease, regulatory molecule and application thereof 上海交通大学医学院 2025-06-24 CN claimed
WO-2025123045-A1 PREDICTIVE AND DIAGNOSTIC SCREENING METHODS FOR ENDOMETRIAL CANCER ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2025-06-12 WO claimed
US-20250170246-A1 CDP-CHOLINE A HOST-DIRECTED THERAPEUTIC FOR DISEASE CAUSED BY SARS COV-2 INFECTION OHIO STATE INNOVATION FOUNDATION 2025-05-29 US claimed
WO-2025101437-A1 MICROALGAE COMPOSITIONS AND METHODS FOR TREATING DISEASE PHYCOIL BIOTECHNOLOGY INTERNATIONAL, INC. (US) 2025-05-15 WO claimed
WO-2025040605-A1 OPHTHALMOLOGICAL COMPOSITION CONTAINING AT LEAST ONE NICOTINIC ACETYLCHOLINE RECEPTOR MODULATOR FOR TOPICAL ADMINISTRATION TO THE EYE FOR PREVENTING OR TREATING INFLAMMATION OF THE EYE URSAPHARM ARZNEIMITTEL GMBH (DE) 2025-02-27 WO claimed
US-20250043255-A1 RECOMBINANT MICROORGANISM USED FOR PRODUCING CDP-CHOLINE, AND METHOD FOR PRODUCING CDP-CHOLINE USING SAID RECOMBINANT MICROORGANISM KYOWA HAKKO BIO CO., LTD. (JP) 2025-02-06 US claimed
US-20240426830-A1 CHRONIC WOUND HEALING BIOMARKER DIAGNOSTICS THE TRUSTEES OF INDIANA UNIVERSITY 2024-12-26 US claimed
WO-2024263144-A1 USE OF CHOLINE COMPRISING NUTRITIONAL SUPPLEMENTS WITH ANALGESIC EFFECTS IN PAIN CAUSED BY FIBROMYALGIA SYNDROME DOKUZ EYLÜL ÜNİVERSİTESİ REKTÖRLÜĞÜ (TR) 2024-12-26 WO claimed
US-4624852-A TRYPTOPHANS AND CHOLINE OR DERIVATIVE MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1986-11-25 US claimed
EP-0188647-A1 Acylated derivatives of cytidine-diphosphate-choline, process for their preparation and their therapeutic use NEOPHARMED S.p.A. (IT) 1986-07-30 EP claimed
EP-0084169-B1 METHOD FOR THE ORAL ADMINISTRATION OF SUBSTANCES IN THE FORM OF LIPOSOMES, AND RELATIVE PHARMACEUTICAL COMPOSITIONS AUSONIA FARMACEUTICI S.r.l. (IT) 1985-09-04 EP claimed
EP-0125900-A1 A pharmaceutical composition for use in treating neurological disease or aging MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1984-11-21 EP claimed
EP-0084169-A1 Method for the oral administration of substances in the form of liposomes, and relative pharmaceutical compositions AUSONIA FARMACEUTICI S.r.l. (IT) 1983-07-27 EP claimed
US-4386078-A CYTIDINE DIPHOSPHOETHANOLAMINES AND CYTIDINEDIPHOSPHOCHOLINE; STROKE, CARDIOVASCULAR DISEASE, INJURIES THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) 1983-05-31 US claimed
US-4386077-A TREATMENT OF CONSCIOUSNESS IMPAIRMENT MADE ITALIANA S.R.L (IT) 1983-05-31 US claimed
EP-0001197-B1 COUPLING PRODUCTS OF CYTIDINE-DIPHOSPHOCHOLINE AND AMINO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL AND ANALYTICAL APPLICATION Etablissement public dit: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (FR) 1981-11-04 EP claimed
US-4203893-A LYSINE RESIDUES OF PROTEINS, AMINOPOLYSACCHARIDES, SYNTHETIC PEPTIDES AND BACTERIASL BODIES INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (FR) 1980-05-20 US claimed
EP-0001197-A2 Coupling products of cytidine-diphosphocholine and amino compounds, process for their preparation and their pharmaceutical and analytical application Etablissement public dit: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (FR) 1979-03-21 EP claimed