Citicoline

Citicoline

SCHEMBL50799

C[N+](C)(C)CCOP(=O)([O-])OP(=O)(O)OCC1OC(n2ccc(N)nc2=O)C(O)C1O

nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.73
GLA P06280 1/20 0.73
P2RY2 P41231 5/20 0.63
ST6GAL1 P15907 9/20 0.59
P2RY6 Q15077 4/20 0.56
P2RY4 P51582 2/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citicoline SCHEMBL31554836 1.00 TSHR (0.73) TSHRGLAP2RY2ST6GAL1P2RY6
Citicoline SCHEMBL31413926 1.00 TSHR (0.73) TSHRGLAP2RY2ST6GAL1P2RY6
Citicoline SCHEMBL221081 1.00 TSHR (0.73) TSHRGLAP2RY2ST6GAL1P2RY6
Citicoline SCHEMBL19347200 0.99 TSHR (0.72) TSHRGLAP2RY2ST6GAL1P2RY6
Citicoline SCHEMBL21906414 0.98 TSHR (0.70) TSHRGLAP2RY2ST6GAL1P2RY6
Citicoline SCHEMBL25411862 0.97 TSHR (0.76) TSHRGLAP2RY2ST6GAL1P2RY6
Citicoline SCHEMBL4311534 0.97 TSHR (0.76) TSHRGLAP2RY2ST6GAL1P2RY6
Citicoline SCHEMBL667104 0.93 TSHR (0.84) TSHRGLAP2RY2ST6GAL1P2RY6
Citicoline SCHEMBL14235352 0.93 P2RY2 (0.70) TSHRGLAP2RY2ST6GAL1P2RY6
Citicoline SCHEMBL13933086 0.93 P2RY2 (0.70) TSHRGLAP2RY2ST6GAL1P2RY6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 11330 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3077548-A2 METHODS FOR DETERMINING DRUG EFFICACY FOR THE TREATMENT OF DIFFUSE LARGE B-CELL LYMPHOMA, MULTIPLE MYELOMA, AND MYELOID CANCERS Celgene Corporation (US) 2016-10-12 EP claimed
CN-103279127-B A kind of only by the GEO orbiter Autonomous Control method of angle information 上海新跃仪表厂 2016-06-22 CN claimed
WO-2015085172-A2 METHODS FOR DETERMINING DRUG EFFICACY FOR THE TREATMENT OF DIFFUSE LARGE B-CELL LYMPHOMA, MULTIPLE MYELOMA, AND MYELOID CANCERS CELGENE CORPORATION (US) 2015-06-11 WO claimed
EP-1858926-A1 SOLUBLE GLYCOSAMINOGLYCANASES AND METHODS OF PREPARING AND USING SOLUBLE GLYCOSAMINOGLYCANASES Halozyme Therapeutics, Inc. (US) 2007-11-28 EP claimed
EP-1740107-A1 ELECTROMAGNETIC TREATMENT APPARATUS AND METHOD IVIVI Technologies, Inc. (US) 2007-01-10 EP claimed
WO-2006091871-A1 SOLUBLE GLYCOSAMINOGLYCANASES AND METHODS OF PREPARING AND USING SOLUBLE GLYCOSAMINOGLYCANASES HALOZYME THERAPEUTICS, INC. (US) 2006-08-31 WO claimed
WO-2005102188-A1 ELECTROMAGNETIC TREATMENT APPARATUS AND METHOD IVIVI TECHNOLOGIES, INC. (US) 2005-11-03 WO claimed
JP-1313467-A None JP disclosed
US-12629533-B2 System and method for precision dosing for electrical stimulation of the brain UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2026-05-19 US disclosed
WO-2026099243-A1 MODIFIED AND UNMODIFIED PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE (PAM) FOR USE IN THE TREATMENT OR PREVENTION OF CEREBRAL HYPOPERFUSION FOR THE IMPROVEMENT OF CEREBRAL BLOOD FLOW (CBF) PAM THERAGNOSTICS GMBH (DE) 2026-05-15 WO disclosed
EP-4741014-A2 DIAGNOSIS OF DEMENTIA BY VASCULAR MAGNETIC RESONANCE IMAGING Northeastern University (US) 2026-05-13 EP disclosed
EP-3856179-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-05-13 EP disclosed
US-12623047-B2 Device, method, and app for facilitating sleep NeuroLight, Inc. (US) 2026-05-12 US disclosed
EP-0229644-A2 Method of use for diltiazem, verapamil or nifedipine having activity for the treatment of stroke WARNER-LAMBERT COMPANY (US) 1987-07-22 EP disclosed
US-4654372-A ALSO NIFEDIPINE AND DILTIAZEM WARNER-LAMBERT COMPANY (US) 1987-03-31 US disclosed
US-4615876-A IMAGING BY SCINTILLATION SCANNING CURATORS OF THE UNIVERSITY OF MISSOURI (US) 1986-10-07 US disclosed
US-4489052-A ADMINISTERING 1-(D-ARABINOFURANOSYL)PYRIMIDINE NUCLEOSIDE AND SCANNING SLOAN-KETTERING FOR CANCER RESEARCH (US) 1984-12-18 US disclosed
US-4263255-A RECEPTOR BINDING KIT FOR ENKEPHALINS BURROUGHS WELLCOME CO. (US) 1981-04-21 US disclosed
US-4257773-A COMPETITIVE BINDING OF ENKEPHALINS TO RECEPTORS BURROUGHS WELLCOME CO. (US) 1981-03-24 US disclosed
US-4231923-A NARCOTICS, OLIGOPEPTIDES, RADIOACTIVITY BURROUGHS WELLCOME CO. (US) 1980-11-04 US disclosed