Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | TBXAS1 | P24557 | 7/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | PTGIS | Q16647 | 1/20 | 0.31 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.31 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27477754 | 0.71 | KDM4E (0.31) | — | |
| Succinic Acid SCHEMBL27888588 | 0.70 | TBXAS1 (0.34) | BCHETBXAS1PTGS1PTGS2PTGIS | |
| SCHEMBL29080941 | 0.64 | TBXAS1 (0.47) | TBXAS1PTGS1PTGS2PTGIS | |
| SCHEMBL25280775 | 0.58 | — | — | |
| Succinic Acid SCHEMBL28637921 | 0.57 | LMNA (0.64) | — | |
| Succinic Acid SCHEMBL8407034 | 0.57 | LMNA (0.64) | — | |
| Succinic Acid SCHEMBL31412754 | 0.57 | HSP90AA1 (0.64) | BCHETBXAS1SHMT2 | |
| Succinic Acid SCHEMBL1898125 | 0.56 | — | — | |
| Succinic Acid SCHEMBL1643227 | 0.56 | — | — | |
| Succinic Acid SCHEMBL11522905 | 0.56 | CYP1A2 (0.61) | SHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020125551-A1 | APPLICATION OF THIOGUANINE IN PREPARATION OF DRUGS FOR TREATMENT, IMPROVEMENT OR PREVENTION OF TUMORS | 广州君赫生物科技有限公司 | 2020-06-25 | — | — | WO | disclosed |
| CN-105229023-B | Peptide MOTS3 from mitochondria adjusts metabolism and cell survival | 加利福尼亚大学董事会 | 2019-08-16 | — | — | CN | disclosed |