Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.36 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22130448 | 0.83 | NPY5R (0.41) | — | |
| SCHEMBL22130446 | 0.81 | LMNA (0.39) | ALDH1A1GAA | |
| SCHEMBL22130474 | 0.75 | NR3C1 (0.32) | — | |
| SCHEMBL447187 | 0.68 | NOTUM (1.00) | NOTUMKDM4EALDH1A1AMPD2CNR2 | |
| SCHEMBL24097911 | 0.66 | NOTUM (0.68) | NOTUMKDM4EALDH1A1AMPD2HSD17B3 | |
| SCHEMBL17446885 | 0.64 | NOTUM (1.00) | NOTUMKDM4EALDH1A1AMPD2HSD17B3 | |
| SCHEMBL31378004 | 0.64 | NOTUM (0.54) | NOTUMKDM4EALDH1A1AMPD2MEN1 | |
| SCHEMBL3459360 | 0.63 | NOTUM (0.66) | NOTUMKDM4EALDH1A1AMPD2HSD17B3 | |
| SCHEMBL2294837 | 0.62 | — | — | |
| SCHEMBL12213334 | 0.62 | NOTUM (0.64) | NOTUMKDM4EALDH1A1AMPD2HSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10688080-B2 | Compositions, methods of use, and methods of treatment | UNIVERSITY OF SOUTH FLORIDA (US) | 2020-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10688080-B2 | Compositions, methods of use, and methods of treatment | LIPA, LCT, GAA | NOTUM 186/4885KDM4E 2498/4885ALDH1A1 1058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.