SCHEMBL221383

SCHEMBL221383

N#Cc1ccc(F)cc1C(F)(F)F

nearest known ligand 0.62

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AR P10275 20/20 0.62
PGR P06401 3/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29421468 0.83 AR (0.50) ARPGR
SCHEMBL325632 0.83 AR (0.50) ARPGR
SCHEMBL5175526 0.83 AR (0.48) ARPGR
SCHEMBL17588986 0.82 AR (0.45) ARPGR
SCHEMBL21332929 0.81 AR (0.75) AR
SCHEMBL5174403 0.81 AR (0.53) ARPGR
SCHEMBL5711220 0.81 AR (0.72) ARPGR
SCHEMBL29891719 0.79 AR (0.43) ARPGR
SCHEMBL6211022 0.79 AR (0.43) ARPGR
SCHEMBL1003776 0.79 AR (0.58) ARPGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 774 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119798228-A PROTAC compound for targeted degradation of AR/AR-V7 and preparation method and application thereof 常州大学 2025-04-11 CN claimed
CN-118315670-A Electrolyte additive and application thereof, single-particle graphite negative electrode electrolyte and application thereof 国网湖南省电力有限公司 2024-07-09 CN claimed
CN-113527130-B Synthesis method of alpha-amide, alpha-aryl quaternary carboketone compound 兰州大学 2023-07-18 CN claimed
CN-113527130-A Synthetic method of alpha-amide and alpha-aryl quaternary carbon ketone compound 兰州大学 2021-10-22 CN claimed
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 US claimed
CN-101759597-B Preparation method of 2-trifluoromethyl-4-aminobenzonitrile SHANGHAI CHEMSPEC INTERNAT LTD 2013-09-04 CN claimed
CN-1810775-B Preparation process of 4-amino-2-trifluoromethyl benzonitrile BAOQING TANG 2012-05-09 CN claimed
CN-101759597-A Preparation method of 2-trifluoromethyl-4-aminobenzonitrile CHEMSPEC INTERNAT LTD 2010-06-30 CN claimed
CN-1810775-A Novel method for preparing 4-amino-2-trifluoromethyl benzonitrile TANG BAOQING (CN) 2006-08-02 CN claimed
EP-4720065-A1 PRMT5 INHIBITORS AND USES THEREOF Insilico Medicine IP Limited (HK) 2026-04-08 EP disclosed
US-12503468-B2 Heterocyclic compound, intermediate, preparation method therefor and application thereof WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD. (CN) 2025-12-23 US disclosed
US-12479807-B2 Methods using HDAC11 inhibitors VALO HEALTH, INC. (US) 2025-11-25 US disclosed
EP-4647431-A1 COMPOUND AND METHOD FOR TARGETED DEGRADATION OF ANDROGEN RECEPTOR Gan & lee Pharm Co., Ltd. (CN) 2025-11-12 EP disclosed
WO-2025217141-A1 PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 ENANTA PHARMACEUTICALS, INC. (US) 2025-10-16 WO disclosed
WO-2002024638-A1 PROCESS FOR THE PREPARATION OF N-(SUBSTITUTED PHENYL)-3-ALKYL-, ARYL- AND HETEROARYLSULFONYL-2-HYDROXY-2-ALKYL- AND HALOALKYLPROPANAMIDE COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY (US) 2002-03-28 WO disclosed
US-20020028832-A1 Heterocyclic beta-3 adrenergic receptor agonists AMERICAN HOME PRODUCTS CORPORATION (US) 2002-03-07 US disclosed
WO-2002006229-A2 HETEROCYCLIC BETA-3 ADRENERGIC RECEPTOR AGONISTS WYETH (US) 2002-01-24 WO disclosed
EP-1122242-A1 CYANOPHENYL DERIVATIVES YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 2001-08-08 EP disclosed
JP-2001097937-A METHOD FOR PRODUCING 4-FLUORO-2- TRIFLUOROMETHYLBENZONITRILE CENTRAL GLASS CO LTD 2001-04-10 JP disclosed
US-6090805-A Tocolytic oxytocin receptor antagonists MERCK & CO., INC. (US) 2000-07-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12479807-B2 Methods using HDAC11 inhibitors HDAC11, HDAC1, HDAC10 AR 2064/4885PGR 3642/4885
US-12503468-B2 Heterocyclic compound, intermediate, preparation method therefor and application thereof P2RX3, P2RX7, P2RX4 AR 1556/4885PGR 2047/4885
US-20020028832-A1 Heterocyclic beta-3 adrenergic receptor agonists ADRB1, ADRB3, ADRB2 AR 438/4885PGR 2965/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.