Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | IL1R1 | P14778 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26290638 | 0.92 | KDM4E (0.33) | L3MBTL1KDM4EATMKMT2AMEN1 | |
| SCHEMBL26289924 | 0.92 | KDM4E (0.33) | L3MBTL1KDM4EATMALDH1A1MAPT | |
| SCHEMBL22145205 | 0.89 | EDNRA (0.34) | L3MBTL1KDM4EATMKMT2AMEN1 | |
| SCHEMBL22145135 | 0.89 | EDNRA (0.36) | KDM4EATMKMT2AMEN1ALDH1A1 | |
| SCHEMBL22145200 | 0.89 | — | — | |
| SCHEMBL22145129 | 0.89 | LMNA (0.36) | L3MBTL1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL26289864 | 0.89 | — | — | |
| SCHEMBL22145208 | 0.88 | SMN1; SMN2 (0.35) | L3MBTL1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL22145204 | 0.87 | L3MBTL1 (0.31) | L3MBTL1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL22145199 | 0.86 | TACR1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898590-B1 | METHOD FOR PREPARING INDOLENAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2023-11-22 | — | — | EP | disclosed |
| EP-3898636-B9 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2023-11-08 | — | — | EP | disclosed |
| EP-3898636-B1 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2023-08-30 | — | — | EP | disclosed |
| US-20220073533-A1 | Method for Preparing Indolenaphthopyrans | TRANSITIONS OPTICAL, LTD. (IE) | 2022-03-10 | — | — | US | disclosed |
| US-20220056039-A1 | Indolonaphthopyrans | TRANSITIONS OPTICAL, LTD. (IE) | 2022-02-24 | — | — | US | disclosed |
| WO-2020126033-A1 | METHOD FOR PREPARING INDOLENAPHTHOPYRANS | TRANSITIONS OPTICAL, LTD. (IE) | 2020-06-25 | — | — | WO | disclosed |
| WO-2020126032-A1 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL, LTD. (IE) | 2020-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220056039-A1 | Indolonaphthopyrans | TPH1, TPH2, IDO1 | L3MBTL1 2877/4885KDM4E 3356/4885ATM 1873/4885 |
| US-20220073533-A1 | Method for Preparing Indolenaphthopyrans | CCNH, CCNT1, PAH | L3MBTL1 1610/4885KDM4E 635/4885ATM 2281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.