Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | OXTR | P30559 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | G6PD | P11413 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22145201 | 0.97 | MAPT (0.36) | EDNRAMAPTLMNAALDH1A1HPGD | |
| SCHEMBL22145205 | 0.96 | EDNRA (0.34) | EDNRAMAPTLMNAALDH1A1HPGD | |
| SCHEMBL22145204 | 0.92 | L3MBTL1 (0.31) | EDNRALMNAALDH1A1HPGDTP53 | |
| SCHEMBL22145250 | 0.91 | KDM4E (0.36) | EDNRAMAPTLMNAALDH1A1HPGD | |
| SCHEMBL22145208 | 0.90 | SMN1; SMN2 (0.35) | EDNRAMAPTLMNAALDH1A1HPGD | |
| SCHEMBL22145126 | 0.90 | PPARG (0.38) | EDNRAMAPTLMNAALDH1A1HPGD | |
| SCHEMBL22145137 | 0.89 | L3MBTL1 (0.37) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL22145207 | 0.89 | KDM4E (0.33) | EDNRAMAPTLMNAALDH1A1HPGD | |
| SCHEMBL23919130 | 0.88 | MAPT (0.36) | EDNRAMAPTLMNAALDH1A1HPGD | |
| SCHEMBL22145210 | 0.88 | ALDH1A1 (0.31) | EDNRAMAPTLMNAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898636-B9 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2023-11-08 | — | — | EP | disclosed |
| EP-3898636-B1 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2023-08-30 | — | — | EP | disclosed |
| US-20220056039-A1 | Indolonaphthopyrans | TRANSITIONS OPTICAL, LTD. (IE) | 2022-02-24 | — | — | US | disclosed |
| WO-2020126032-A1 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL, LTD. (IE) | 2020-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220056039-A1 | Indolonaphthopyrans | TPH1, TPH2, IDO1 | EDNRA 204/4885MAPT 1575/4885LMNA 2683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.