Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22145208 | 0.95 | SMN1; SMN2 (0.35) | KDM4EMEN1ALDH1A1HPGDHTT | |
| SCHEMBL22145205 | 0.93 | EDNRA (0.34) | KDM4EMEN1ALDH1A1HPGDHTT | |
| SCHEMBL22145201 | 0.92 | MAPT (0.36) | KDM4EMEN1ALDH1A1HPGDHTT | |
| SCHEMBL22145191 | 0.91 | PPARG (0.32) | PPARG | |
| SCHEMBL22145250 | 0.91 | KDM4E (0.36) | KDM4EMEN1ALDH1A1HPGDHTT | |
| SCHEMBL22145214 | 0.90 | PPARG (0.40) | MEN1ALDH1A1KMT2AHSD17B10LMNA | |
| SCHEMBL22145210 | 0.90 | ALDH1A1 (0.31) | KDM4EMEN1ALDH1A1HPGDHTT | |
| SCHEMBL22145135 | 0.89 | EDNRA (0.36) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL22145204 | 0.87 | L3MBTL1 (0.31) | KDM4EMEN1ALDH1A1HPGDHTT | |
| SCHEMBL22145193 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898636-B1 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2023-08-30 | — | — | EP | disclosed |
| US-20220056039-A1 | Indolonaphthopyrans | TRANSITIONS OPTICAL, LTD. (IE) | 2022-02-24 | — | — | US | disclosed |
| WO-2020126032-A1 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL, LTD. (IE) | 2020-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220056039-A1 | Indolonaphthopyrans | TPH1, TPH2, IDO1 | KDM4E 3356/4885MEN1 1845/4885ALDH1A1 230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.