Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22146147 | 0.90 | EPHB4 (0.36) | LMNAPKMPOLBMEN1KMT2A | |
| SCHEMBL22146193 | 0.89 | EPHB4 (0.39) | LMNAPKMPOLBMEN1KMT2A | |
| SCHEMBL22146197 | 0.87 | LMNA (0.43) | LMNAPKMPOLBMEN1KMT2A | |
| SCHEMBL18965126 | 0.84 | EPHB4 (0.49) | LMNAPKMEPHB4GRIN1GRIN2B | |
| SCHEMBL22146189 | 0.84 | NOTUM (0.36) | LMNAPKMEPHB4 | |
| SCHEMBL22146148 | 0.84 | LMNA (0.41) | LMNAPKMPOLBMEN1KMT2A | |
| SCHEMBL22146209 | 0.79 | NPSR1 (0.34) | LMNAPKMNPSR1EPHB4 | |
| SCHEMBL22146201 | 0.78 | PKM (0.45) | LMNAPKMPOLBMEN1KMT2A | |
| SCHEMBL22146195 | 0.78 | EPHB4 (0.37) | LMNAPKMNPSR1EPHB4 | |
| SCHEMBL22146154 | 0.76 | TRPA1 (0.36) | LMNAPKMEPHB4GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3386591-B1 | HETEROAROMATIC NMDA RECEPTOR MODULATORS AND USES THEREOF | CADENT THERAPEUTICS INC (US) | 2020-06-24 | — | — | EP | disclosed |