Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | RHOA | P61586 | 1/20 | 0.41 |
| ▸ | SPR | P35270 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2214743 | 0.89 | VNN1 (0.47) | CYP3A4KMT2AMEN1PKMLMNA | |
| SCHEMBL302916 | 0.88 | KMT2A (0.46) | CYP3A4KMT2AMEN1PKMLMNA | |
| SCHEMBL303319 | 0.88 | LMNA (0.48) | CYP3A4KMT2AMEN1PKMLMNA | |
| SCHEMBL2209547 | 0.88 | LMNA (0.43) | KMT2ALMNASPRHTTNPSR1 | |
| SCHEMBL2209550 | 0.87 | GRM5 (0.38) | KMT2AMEN1LMNARHOASPR | |
| SCHEMBL2246857 | 0.81 | MEN1 (0.65) | KMT2AMEN1PKMLMNAHTT | |
| SCHEMBL2188728 | 0.80 | SPR (0.49) | KMT2AMEN1PKMLMNASPR | |
| SCHEMBL301712 | 0.79 | GRM5 (0.52) | KMT2AMEN1PKMLMNASPR | |
| SCHEMBL2186628 | 0.79 | GRM5 (0.49) | KMT2AMEN1LMNAL3MBTL1SPR | |
| SCHEMBL307512 | 0.78 | GRM5 (0.48) | KMT2AMEN1LMNAL3MBTL1SPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342177-B1 | NOVEL POTASSIUM CHANNEL BLOCKERS | JAPAN TOBACCO INC (JP) | 2017-02-15 | — | — | EP | claimed |
| JP-2012500836-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | claimed |