Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26979174 | 0.91 | KMT2A (0.56) | TSHRKMT2ACYP1A2GALR3NR2F2 | |
| SCHEMBL18732125 | 0.83 | ALDH1A1 (0.45) | TSHRCYP1A2GALR3NR2F2LMNA | |
| SCHEMBL14247241 | 0.82 | BACE1 (0.58) | KMT2ACYP1A2LMNATP53HTT | |
| SCHEMBL23042330 | 0.82 | MTNR1A (0.45) | TSHRKMT2ALMNATP53HTT | |
| SCHEMBL17678058 | 0.81 | P2RX7 (0.46) | TSHRCYP1A2GALR3NR2F2LMNA | |
| SCHEMBL21803208 | 0.80 | KDM4E (0.51) | TSHRKMT2ACYP1A2GALR3NR2F2 | |
| SCHEMBL18732123 | 0.79 | PKM (0.46) | TSHRKMT2ACYP1A2GALR3NR2F2 | |
| SCHEMBL22152416 | 0.79 | HDAC1 (0.39) | KMT2ALMNATP53HTTMAPT | |
| SCHEMBL21025767 | 0.78 | LMNA (0.58) | LMNAMAPT | |
| SCHEMBL22122305 | 0.77 | GALR3 (0.42) | TSHRKMT2AGALR3NR2F2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020132597-A1 | COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF | Revolution Medicines, Inc. (US) | 2020-06-25 | — | — | WO | disclosed |