Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 9/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 6/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | GABRE | P78334 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26622785 | 0.84 | ALOX15 (0.40) | CA12CA1CA2CA9CA14 | |
| SCHEMBL6141564 | 0.84 | ALOX15 (0.41) | CA12CA1CA2CA9CA14 | |
| SCHEMBL29826371 | 0.82 | MAPK1 (0.50) | HTTKMT2ACA12CA1CA2 | |
| SCHEMBL3346590 | 0.82 | MAPK1 (0.50) | HTTKMT2ACA12CA1CA2 | |
| SCHEMBL8806697 | 0.82 | HTT (0.48) | HTTKMT2AGABRG2GABRB3GABRA1 | |
| SCHEMBL2132762 | 0.81 | GABRG2 (0.41) | CA12CA1CA2CA9CA14 | |
| SCHEMBL3705490 | 0.81 | GABRA1 (0.37) | CA12CA1CA2CA9CA14 | |
| SCHEMBL13574670 | 0.81 | CA12 (0.37) | CA12CA1CA2CA9CA14 | |
| SCHEMBL27939903 | 0.81 | CA12 (0.38) | CA12CA1CA2CA9CA14 | |
| SCHEMBL27516326 | 0.80 | GABRA1 (0.38) | KMT2ACA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103626693-B | One class pleuromutilin derivative, its pharmaceutical composition and synthetic method thereof and purposes | 中国科学院上海药物研究所 | 2016-09-14 | — | — | CN | disclosed |
| US-20110178053-A1 | AZACARBOLINE DERIVATIVES, PREPARATION METHOD THEREOF AND THERAPEUTIC USE OF SAME | SANOFI-AVENTIS (FR) | 2011-07-21 | — | — | US | disclosed |
| US-20110178053-A1 | AZACARBOLINE DERIVATIVES, PREPARATION METHOD THEREOF AND THERAPEUTIC USE OF SAME | SANOFI-AVENTIS (FR) | 2011-07-21 | — | — | US | disclosed |
| US-20110178053-A1 | AZACARBOLINE DERIVATIVES, PREPARATION METHOD THEREOF AND THERAPEUTIC USE OF SAME | SANOFI-AVENTIS (FR) | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178053-A1 | AZACARBOLINE DERIVATIVES, PREPARATION METHOD THEREOF AND THERAPEUTIC USE OF SAME | AOC3, CBR3, IDH3B | HTT 954/4885KMT2A 891/4885CA12 979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.