⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13274125 | 0.78 | L3MBTL1 (0.31) | — | |
| SCHEMBL19699508 | 0.78 | MME (0.33) | — | |
| SCHEMBL22046874 | 0.76 | L3MBTL1 (0.30) | — | |
| SCHEMBL31560708 | 0.74 | OPRM1 (0.37) | — | |
| SCHEMBL31560579 | 0.74 | FFAR2 (0.41) | — | |
| SCHEMBL31560763 | 0.72 | UTS2R (0.37) | — | |
| SCHEMBL20043193 | 0.72 | MAOB (0.31) | — | |
| SCHEMBL31560651 | 0.71 | HSD11B1 (0.45) | — | |
| SCHEMBL31560741 | 0.71 | SLC6A4 (0.38) | — | |
| SCHEMBL23205080 | 0.71 | CCR2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11220506-B2 | Imidazo[1,5-a]pyrazine derivatives as PI3Kdelta inhibitors | BEIGENE, LTD. (KY) | 2022-01-11 | — | — | US | disclosed |
| US-20200207774-A1 | IMIDAZO[1,5-A]PYRAZINE DERIVATIVES AS PI3KDELTA INHIBITORS | BEONE MEDICINES I GMBH (CH) | 2020-07-02 | — | — | US | disclosed |