Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | TNNC1 | P63316 | 6/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.38 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.37 |
| ▸ | TUBB | P07437 | 2/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2215035 | 1.00 | TDP1 (0.47) | TDP1LMNAGAAEGFRTNNC1 | |
| SCHEMBL2219057 | 1.00 | TDP1 (0.47) | TDP1LMNAGAAEGFRTNNC1 | |
| SCHEMBL2361798 | 0.87 | GAA (0.41) | TDP1LMNAGAA | |
| SCHEMBL8055183 | 0.74 | TDP1 (0.52) | TDP1LMNAEGFRTUBB4ATUBB | |
| SCHEMBL23406262 | 0.70 | EGFR (0.50) | TDP1LMNAGAAEGFRTUBB4A | |
| Alcohol SCHEMBL10990969 | 0.70 | EGFR (0.47) | TDP1LMNAGAAEGFRTNNC1 | |
| SCHEMBL2362850 | 0.70 | ALDH1A1 (0.39) | LMNA | |
| SCHEMBL10011783 | 0.69 | SIGMAR1 (0.42) | GAATNNC1S1PR1SGPL1S1PR4 | |
| SCHEMBL1238436 | 0.68 | ALDH1A1 (0.40) | LMNA | |
| SCHEMBL31718808 | 0.68 | TDP1 (0.65) | TDP1LMNAEGFRTUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110177156-A1 | Sterol-Modified Amphiphilic Lipids | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2011-07-21 | — | — | US | disclosed |
| CN-101909581-A | Sterol-modified amphiphilic lipids | UNIV CALIFORNIA | 2010-12-08 | — | — | CN | disclosed |
| EP-2219587-A1 | STEROL-MODIFIED AMPHIPHILIC LIPIDS | The Regents of the University of California (US) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009064696-A1 | STEROL-MODIFIED AMPHIPHILIC LIPIDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110177156-A1 | Sterol-Modified Amphiphilic Lipids | SREBF1, SREBF2, SGMS1 | TDP1 3661/4885LMNA 500/4885GAA 1616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.