Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.33 |
| ▸ | ELANE | P08246 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646189 | 0.80 | CYP3A4 (0.34) | LMNAADRB2ADRB1ADRB3ELANE | |
| SCHEMBL2217364 | 0.76 | ALDH1A1 (0.35) | LMNAADRB2ADRB1ADRB3ELANE | |
| SCHEMBL1409148 | 0.76 | ALDH1A1 (0.35) | LMNAADRB2ADRB1ADRB3ELANE | |
| SCHEMBL4439353 | 0.71 | CYP3A4 (0.58) | ELANEALDH1A1HPGDCYP3A4HSD17B10 | |
| SCHEMBL311041 | 0.69 | KLK5 (0.36) | ADRB2ADRB1ADRB3ALDH1A1HPGD | |
| SCHEMBL646188 | 0.67 | CASP1 (0.44) | CASP1 | |
| SCHEMBL3905732 | 0.67 | ADRB2 (0.38) | LMNAADRB2ADRB1ADRB3ELANE | |
| SCHEMBL3905740 | 0.67 | ADRB2 (0.38) | LMNAADRB2ADRB1ADRB3ELANE | |
| SCHEMBL8766597 | 0.66 | ALDH1A1 (0.59) | ALDH1A1HPGDCYP3A4HSD17B10TSHR | |
| SCHEMBL7028882 | 0.64 | CYP3A4 (0.65) | ALDH1A1HPGDCYP3A4HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110178069-A1 | INHIBITORS OF INTERLEUKIN-1 BETA CONVERTING ENZYME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178069-A1 | INHIBITORS OF INTERLEUKIN-1 BETA CONVERTING ENZYME | IL1A, IFNAR1, IL1B | LMNA 485/4885ADRB2 3689/4885ADRB1 2121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.