Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 3/20 | 0.44 |
| ▸ | ACE | P12821 | 2/20 | 0.44 |
| ▸ | CPA1 | P15085 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | ECE1 | P42892 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13480148 | 0.89 | ALDH1A1 (0.44) | TDP1ALDH1A1LMNAMAPTPTGS2 | |
| SCHEMBL12766447 | 0.85 | HDAC7 (0.36) | TDP1ALDH1A1LMNAMAPTPTGS2 | |
| SCHEMBL13958540 | 0.82 | HDAC7 (0.40) | TDP1ALDH1A1MMEFAAHCTSS | |
| SCHEMBL6848366 | 0.82 | HDAC7 (0.40) | TDP1ALDH1A1MMEFAAHCTSS | |
| SCHEMBL16203680 | 0.81 | GLO1 (0.47) | TDP1ALDH1A1LMNAMAPTPTGS2 | |
| SCHEMBL19778726 | 0.80 | ALDH1A1 (0.47) | TDP1ALDH1A1LMNAMAPTPTGS2 | |
| SCHEMBL22622472 | 0.80 | LMNA (0.43) | TDP1ALDH1A1LMNAMAPTPTGS2 | |
| SCHEMBL14537553 | 0.79 | ALDH1A1 (0.42) | TDP1ALDH1A1LMNAMAPTPTGS2 | |
| SCHEMBL4017322 | 0.78 | HDAC7 (0.56) | TDP1ALDH1A1LMNAMAPTPTGS2 | |
| SCHEMBL19769984 | 0.78 | CTSS (0.47) | TDP1ALDH1A1LMNAMAPTPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3078656-B1 | AMIDE DERIVATIVES OF N-UREA SUBSTITUTED AMINO ACIDS AS FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS | ALLERGAN INC (US) | 2020-07-01 | — | — | EP | disclosed |