Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HEXA | P06865 | 1/20 | 0.37 |
| ▸ | HEXB | P07686 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22181855 | 0.84 | TP53 (0.53) | TP53HEXAHEXBPOLBKDM4E | |
| SCHEMBL22182070 | 0.77 | HEXA (0.36) | HEXAHEXBPOLBALDH1A1MAPT | |
| SCHEMBL22181838 | 0.75 | HDAC3 (0.35) | HEXAHEXBPOLBKDM4EALDH1A1 | |
| SCHEMBL22182069 | 0.73 | CA12 (0.37) | POLBKDM4EALDH1A1GAAMAPT | |
| SCHEMBL22181915 | 0.73 | ALDH1A1 (0.57) | HEXAHEXBPOLBKDM4EALDH1A1 | |
| SCHEMBL22181998 | 0.73 | SIRT1 (0.53) | HEXAHEXBPOLBKDM4EALDH1A1 | |
| SCHEMBL22181899 | 0.73 | MEN1 (0.56) | HEXAHEXBPOLBKDM4EALDH1A1 | |
| SCHEMBL22182108 | 0.70 | USP2 (0.41) | HEXAHEXBPOLBKDM4EALDH1A1 | |
| SCHEMBL22182064 | 0.70 | ALDH1A1 (0.52) | HEXAHEXBPOLBKDM4EALDH1A1 | |
| SCHEMBL8243456 | 0.70 | HDAC8 (0.65) | KDM4EALDH1A1GAAKMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020139291-A1 | NAPHTHALIMIDE DERIVATIVES AS ANTI-PARASITIC AGENTS FOR THE TREATMENT OF LEISHMANIASIS AS WELL AS VIRAL, BACTERIAL AND NEOPLASTIC DISEASES | ISTANBUL MEDIPOL UNIVERSITESI (TR) | 2020-07-02 | — | — | WO | disclosed |