Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 | P47900 | 2/20 | 0.48 |
| ▸ | FUT8 | Q9BYC5 | 2/20 | 0.48 |
| ▸ | P2RY4 | P51582 | 4/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | APEX1 | P27695 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2203248 | 0.98 | P2RY1 (0.49) | P2RY1FUT8P2RY4USP2APEX1 | |
| SCHEMBL2204424 | 0.92 | CHAT (0.44) | P2RY1FUT8P2RY4USP2APEX1 | |
| SCHEMBL2220866 | 0.92 | CHAT (0.44) | P2RY1FUT8P2RY4USP2APEX1 | |
| SCHEMBL2206198 | 0.88 | HPGDS (0.48) | P2RY1FUT8P2RY4USP2APEX1 | |
| Potassium SCHEMBL2218600 | 0.88 | HPGDS (0.48) | P2RY1FUT8P2RY4USP2APEX1 | |
| SCHEMBL2203266 | 0.88 | CHAT (0.48) | P2RY1FUT8P2RY4USP2APEX1 | |
| Potassium Ion SCHEMBL2202992 | 0.87 | CA12 (0.56) | P2RY1FUT8P2RY4USP2APEX1 | |
| SCHEMBL2200580 | 0.87 | HPGDS (0.47) | P2RY1FUT8P2RY4USP2APEX1 | |
| Potassium Ion SCHEMBL2203845 | 0.86 | CA12 (0.55) | P2RY1FUT8P2RY4USP2APEX1 | |
| SCHEMBL11879420 | 0.85 | CA12 (0.56) | P2RY1FUT8P2RY4USP2APEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546300-B2 | Thermosensitive recording material and image recording method | RICOH COMPANY, LTD. (JP) | 2013-10-01 | — | — | US | disclosed |
| US-20110177941-A1 | THERMOSENSITIVE RECORDING MATERIAL AND IMAGE RECORDING METHOD | RICOH COMPANY, LTD. (JP) | 2011-07-21 | — | — | US | disclosed |