SCHEMBL22187652

SCHEMBL22187652

Oc1ccc(C2(c3ccc(O)c(-c4ccccc4)c3)c3ccc(-c4ccccc4)cc3-c3cc(-c4ccccc4)ccc32)cc1-c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B1 P14061 1/20 0.48
HSD17B2 P37059 1/20 0.48
ESR2 Q92731 2/20 0.46
ESR1 P03372 1/20 0.46
ALOX5 P09917 2/20 0.46
BACE1 P56817 2/20 0.46
ALDH1A1 P00352 3/20 0.42
HPGD P15428 2/20 0.42
HSD17B10 Q99714 2/20 0.42
KDM4E B2RXH2 1/20 0.42
MEN1 O00255 1/20 0.42
USP2 O75604 1/20 0.42
LMNA P02545 1/20 0.42
HSP90AA1 P07900 1/20 0.42
GAA P10253 1/20 0.42
MAPT P10636 1/20 0.42
ALOX15 P16050 1/20 0.42
ALOX12 P18054 1/20 0.42
HTT P42858 1/20 0.42
KMT2A Q03164 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22187669 0.90 HSD17B1 (0.52) HSD17B1HSD17B2ESR2ESR1ALOX5
SCHEMBL22187643 0.88 ESR2 (0.46) HSD17B1HSD17B2ESR2ESR1ALOX5
SCHEMBL17352706 0.88 ESR2 (0.54) HSD17B1HSD17B2ESR2ESR1ALOX5
SCHEMBL29837106 0.85 ESR1 (0.63) HSD17B1HSD17B2ESR2ESR1ALOX5
SCHEMBL218750 0.85 ESR1 (0.63) HSD17B1HSD17B2ESR2ESR1ALOX5
SCHEMBL29389637 0.85 ESR1 (0.63) HSD17B1HSD17B2ESR2ESR1ALOX5
SCHEMBL22187705 0.85 ESR2 (0.68) HSD17B1HSD17B2ESR2ESR1ALOX5
SCHEMBL22187714 0.84 MCL1 (0.50) HSD17B1HSD17B2ESR2ESR1BACE1
SCHEMBL29601892 0.82 MMP3 (0.52) HSD17B1HSD17B2ESR2ESR1ALOX5
SCHEMBL2674735 0.82 MMP3 (0.52) HSD17B1HSD17B2ESR2ESR1ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12441880-B2 Poly(ester)carbonate and method for producing poly(ester)carbonate TEIJIN LIMITED (JP) 2025-10-14 US disclosed
EP-3733734-B1 POLY(ESTER)CARBONATE AND METHOD FOR PRODUCING POLY(ESTER)CARBONATE TEIJIN LTD (JP) 2024-03-06 EP disclosed
US-20230051676-A1 POLYCARBONATE AND METHOD FOR PRODUCING POLYCARBONATE TEIJIN LIMITED (JP) 2023-02-16 US disclosed
US-11505698-B2 Polyester carbonate and method for producing polyester carbonate TEIJIN LIMITED (JP) 2022-11-22 US disclosed
US-11339249-B2 Compound having fluorene skeleton, and method for manufacturing same TEIJIN LIMITED (JP) 2022-05-24 US disclosed
US-11261294-B2 Thermoplastic resin and optical member TEIJIN LIMITED (JP) 2022-03-01 US disclosed
US-20210371650-A1 POLY(ESTER)CARBONATE AND METHOD FOR PRODUCING POLY(ESTER)CARBONATE TEIJIN LIMITED (JP) 2021-12-02 US disclosed
US-20210147621-A1 THERMOPLASTIC RESIN AND OPTICAL MEMBER TEIJIN LIMITED (JP) 2021-05-20 US disclosed
EP-3747856-A1 COMPOUND HAVING FLUORENE SKELETON, AND METHOD FOR MANUFACTURING SAME Teijin Limited (JP) 2020-12-09 EP disclosed
US-20200354517-A1 COMPOUND HAVING FLUORENE SKELETON, AND METHOD FOR MANUFACTURING SAME TEIJIN LIMITED (JP) 2020-11-12 US disclosed
EP-3733734-A1 POLY(ESTER)CARBONATE AND METHOD FOR PRODUCING POLY(ESTER)CARBONATE Teijin Limited (JP) 2020-11-04 EP disclosed
EP-3677614-A1 THERMOPLASTIC RESIN AND OPTICAL MEMBER Teijin Limited (JP) 2020-07-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200354517-A1 COMPOUND HAVING FLUORENE SKELETON, AND METHOD FOR MANUFACTURING SAME RFT1, AFF1, RER1 HSD17B1 847/4885HSD17B2 989/4885ESR2 1835/4885
US-11339249-B2 Compound having fluorene skeleton, and method for manufacturing same RFT1, AFF1, RER1 HSD17B1 847/4885HSD17B2 989/4885ESR2 1835/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.