Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HMGCR | P04035 | 3/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | BAD | Q92934 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22188195 | 0.85 | ELANE (0.43) | HMGCRPTGDR2NOTUM | |
| SCHEMBL22188215 | 0.85 | KDM4E (0.43) | KDM4EALDH1A1TDP1L3MBTL1HMGCR | |
| SCHEMBL22188193 | 0.82 | GRIA2 (0.43) | KDM4EALDH1A1TDP1L3MBTL1PTGDR2 | |
| SCHEMBL21776525 | 0.77 | SMN1; SMN2 (0.41) | KDM4EALDH1A1PTGDR2LMNA | |
| SCHEMBL9751010 | 0.75 | HMGCR (0.49) | KDM4EALDH1A1TDP1L3MBTL1HMGCR | |
| SCHEMBL29720900 | 0.74 | TGFBR1 (0.42) | TDP1HMGCRPTGDR2ADORA2AADORA1 | |
| SCHEMBL29811072 | 0.74 | ELANE (0.43) | HMGCRPTGDR2 | |
| SCHEMBL9764350 | 0.73 | KDM4E (0.43) | KDM4EALDH1A1TDP1L3MBTL1HMGCR | |
| Hydrochloric Acid SCHEMBL29812369 | 0.73 | ELANE (0.42) | HMGCRPTGDR2 | |
| SCHEMBL23147433 | 0.72 | NOTUM (0.42) | KDM4EALDH1A1BCL2L1BADLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020141470-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | ARRAY BIOPHARMA INC. (US) | 2020-07-09 | — | — | WO | disclosed |
| US-20200216416-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | ARRAY BIOPHARMA INC. (US) | 2020-07-09 | — | — | US | disclosed |
| US-20200216416-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | ARRAY BIOPHARMA INC. (US) | 2020-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200216416-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | RET, MET, MERTK | KDM4E 848/4885ALDH1A1 2830/4885TDP1 3208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.