Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20501825 | 0.75 | CSF1R (0.37) | LMNABLMPTGS1CSF1RALDH1A1 | |
| SCHEMBL6422740 | 0.67 | GRIA1 (0.49) | LMNABLMTDP1PTGS1GRIA1 | |
| SCHEMBL21853771 | 0.66 | LMNA (0.58) | LMNABLMTDP1NR1I2PTGS1 | |
| SCHEMBL21853772 | 0.66 | LMNA (0.58) | LMNABLMTDP1NR1I2PTGS1 | |
| SCHEMBL2759117 | 0.65 | — | — | |
| SCHEMBL13957618 | 0.65 | LMNA (0.43) | LMNABLMTDP1NR1I2PTGS1 | |
| SCHEMBL9320152 | 0.64 | ACHE (0.58) | LMNABLMPTGS1ADRA1AACHE | |
| SCHEMBL3101768 | 0.64 | PTPRA (0.37) | LMNABLMCSF1RGRIA1GRIA3 | |
| SCHEMBL21853765 | 0.63 | SLC1A2 (0.45) | LMNABLMTDP1NR1I2PTGS1 | |
| SCHEMBL21853764 | 0.63 | SLC1A2 (0.45) | LMNABLMTDP1NR1I2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240141291-A1 | FUNCTIONAL BRAIN REGION-SPECIFIC NEURAL SPHEROIDS AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES | 2024-05-02 | — | — | US | disclosed |
| WO-2024044355-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER NEUROGENERATIVE DISEASE | 1/1THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2024-02-29 | — | — | WO | disclosed |
| US-20200215147-A1 | METHODS FOR TREATING DEPRESSION AND MAJOR DEPRESSIVE DISORDER | CARMEL HAIFA UNIVERSITY ECONOMIC CORPORATION LTD. (IL) | 2020-07-09 | — | — | US | disclosed |