Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 7/20 | 0.46 |
| ▸ | DRD2 | P14416 | 6/20 | 0.46 |
| ▸ | HTR1A | P08908 | 5/20 | 0.46 |
| ▸ | DRD4 | P21917 | 5/20 | 0.46 |
| ▸ | HTR2A | P28223 | 4/20 | 0.46 |
| ▸ | DRD1 | P21728 | 3/20 | 0.46 |
| ▸ | DRD5 | P21918 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | HTR7 | P34969 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22197947 | 0.91 | DRD2 (0.43) | DRD3DRD2HTR1ADRD4HTR2A | |
| SCHEMBL22197917 | 0.87 | DRD2 (0.46) | DRD3DRD2HTR1ADRD4HTR2A | |
| SCHEMBL25516155 | 0.85 | DRD2 (0.46) | DRD3DRD2HTR1ADRD4HTR2A | |
| SCHEMBL19748777 | 0.85 | DRD2 (0.50) | DRD3DRD2HTR1ADRD4HTR2A | |
| SCHEMBL22197978 | 0.81 | MAPT (0.42) | DRD3DRD2DRD1DRD5KDM4E | |
| SCHEMBL1646151 | 0.81 | DRD3 (0.51) | DRD3DRD2HTR1ADRD4HTR2A | |
| SCHEMBL22197948 | 0.81 | HTR3A (0.46) | — | |
| SCHEMBL14130867 | 0.76 | MAPT (0.45) | — | |
| SCHEMBL4287978 | 0.76 | DRD2 (0.53) | DRD2HTR7KDM4E | |
| SCHEMBL22792172 | 0.74 | DRD3 (0.53) | DRD3DRD2HTR1ADRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142228-A1 | ANDROGEN RECEPTOR PROTEIN DEGRADERS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-07-09 | — | — | WO | disclosed |