Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.43 |
| ▸ | DRD1 | P21728 | 3/20 | 0.43 |
| ▸ | DRD5 | P21918 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22197868 | 0.91 | DRD3 (0.46) | DRD2DRD1DRD5DRD3SIGMAR1 | |
| SCHEMBL22197917 | 0.85 | DRD2 (0.46) | DRD2DRD1DRD5DRD3SIGMAR1 | |
| SCHEMBL4287978 | 0.84 | DRD2 (0.53) | DRD2RETHTR7KDM4EPARP1 | |
| SCHEMBL22197978 | 0.84 | MAPT (0.42) | DRD2DRD1DRD5DRD3MAPT | |
| SCHEMBL22197948 | 0.84 | HTR3A (0.46) | MAPTPIK3CAMTOR | |
| SCHEMBL25516155 | 0.80 | DRD2 (0.46) | DRD2DRD1DRD5DRD3SIGMAR1 | |
| SCHEMBL14130867 | 0.80 | MAPT (0.45) | MAPTPIK3CAMTOR | |
| SCHEMBL15496957 | 0.78 | DRD2 (0.60) | DRD2DRD1DRD5DRD3SIGMAR1 | |
| SCHEMBL14130936 | 0.77 | PLD1 (0.46) | RETMAPTHTR7HTR1AHTR2C | |
| SCHEMBL8218487 | 0.77 | ADK (0.60) | MAPTKDM4EGAAPIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142228-A1 | ANDROGEN RECEPTOR PROTEIN DEGRADERS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-07-09 | — | — | WO | disclosed |