SCHEMBL22199865

SCHEMBL22199865

c1ccc(-c2ccc(-c3ccc4nc(-n5c6ccccc6c6c7ccccc7c7c8ccccc8oc7c65)ccc4n3)cc2)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.32
TDO2 P48775 1/20 0.32
RAB9A P51151 1/20 0.32
ACHE P22303 1/20 0.31
MEN1 O00255 2/20 0.31
MAPT P10636 2/20 0.31
KMT2A Q03164 2/20 0.31
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
POLB P06746 1/20 0.31
GAA P10253 1/20 0.31
TSHR P16473 1/20 0.31
ALOX12 P18054 1/20 0.31
MAPK1 P28482 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
DHODH Q02127 2/20 0.30
CSF1R P07333 1/20 0.30
PDGFRB P09619 1/20 0.30
KIT P10721 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22199931 0.98 NPC1 (0.33) NPC1TDO2RAB9AACHEMEN1
SCHEMBL22200000 0.89 TUBB4A (0.34) NPC1RAB9AMEN1MAPTKMT2A
SCHEMBL22200009 0.87 KDM4E (0.33) MEN1KMT2AALDH1A1LMNAPOLB
SCHEMBL16866927 0.85 SMN1; SMN2 (0.32) TDO2ALDH1A1LMNANPSR1
SCHEMBL22199813 0.83 L3MBTL1 (0.36) TDO2MEN1MAPTKMT2AALDH1A1
SCHEMBL22199864 0.82
SCHEMBL19039945 0.82 EGFR (0.42) NPC1RAB9AMAPTALDH1A1LMNA
SCHEMBL22199815 0.81 L3MBTL1 (0.38) NPC1TDO2ACHEMEN1MAPT
SCHEMBL19039793 0.80 NPC1 (0.44) NPC1RAB9AMEN1MAPTKMT2A
SCHEMBL18805448 0.79 EGFR (0.43) NPC1RAB9AMAPTALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200216392-A1 A PLURALITY OF HOST MATERIALS AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME DUPONT SPECIALTY MATERIALS KOREA LTD. (KR) 2020-07-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200216392-A1 A PLURALITY OF HOST MATERIALS AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME TERF2, PIEZO1, TERT NPC1 3704/4885TDO2 1681/4885RAB9A 1232/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.