Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | FPR2 | P25090 | 1/20 | 0.45 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.44 |
| ▸ | BCL6 | P41182 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201003 | 0.82 | EPHX2 (0.66) | ALDH1A1POLBNAMPT | |
| SCHEMBL10587520 | 0.77 | ALDH1A1 (0.64) | ALDH1A1POLBMAPTKDM4EGAA | |
| SCHEMBL10432097 | 0.76 | ALDH1A1 (0.65) | ALDH1A1POLBMAPTKDM4EGAA | |
| SCHEMBL15349076 | 0.74 | ALDH1A1 (0.60) | ALDH1A1POLBMAPTKDM4EGAA | |
| SCHEMBL7453800 | 0.73 | EPHX1 (0.70) | ALDH1A1POLBNAMPTFPR2 | |
| SCHEMBL6778508 | 0.72 | GBA1 (0.51) | ALDH1A1POLBNAMPT | |
| SCHEMBL15510403 | 0.71 | MAPT (0.74) | ALDH1A1MAPTKDM4E | |
| SCHEMBL5528440 | 0.70 | FPR2 (0.61) | ALDH1A1POLBNAMPTFPR2 | |
| SCHEMBL9672087 | 0.70 | ALDH1A1 (0.54) | ALDH1A1POLBMAPTKDM4EGAA | |
| SCHEMBL29972743 | 0.69 | ALDH1A1 (0.57) | ALDH1A1MAPTKDM4ENAMPTATG4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11773075-B2 | Modulators of p97 AAA ATPase activity | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2023-10-03 | — | — | US | disclosed |
| US-11773075-B2 | Modulators of p97 AAA ATPase activity | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2023-10-03 | — | — | US | disclosed |
| US-11773075-B2 | Modulators of p97 AAA ATPase activity | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2023-10-03 | — | — | US | disclosed |
| US-20220089565-A1 | MODULATORS OF P97 AAA ATPASE ACTIVITY | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2022-03-24 | — | — | US | disclosed |
| US-20220089565-A1 | MODULATORS OF P97 AAA ATPASE ACTIVITY | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2022-03-24 | — | — | US | disclosed |
| US-11214560-B2 | Modulators of P97 AAA ATPase activity | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2022-01-04 | — | — | US | disclosed |
| US-11214560-B2 | Modulators of P97 AAA ATPase activity | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2022-01-04 | — | — | US | disclosed |
| US-20200216410-A1 | MODULATORS OF P97 AAA ATPASE ACTIVITY | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | US | disclosed |
| US-20200216410-A1 | MODULATORS OF P97 AAA ATPASE ACTIVITY | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | US | disclosed |
| WO-2018209083-A1 | MODULATORS OF P97 AAA ATPASE ACTIVITY | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220089565-A1 | MODULATORS OF P97 AAA ATPASE ACTIVITY | PSMG3, CDC37, AHSA1 | ALDH1A1 3583/4885POLB 686/4885MAPT 370/4885 |
| US-20200216410-A1 | MODULATORS OF P97 AAA ATPASE ACTIVITY | PSMG3, AHSA1, CDC37 | ALDH1A1 3652/4885POLB 747/4885MAPT 452/4885 |
| US-11214560-B2 | Modulators of P97 AAA ATPase activity | PSMG3, AHSA1, CDC37 | ALDH1A1 3652/4885POLB 747/4885MAPT 452/4885 |
| US-11773075-B2 | Modulators of p97 AAA ATPase activity | PSMG3, CDC37, AHSA1 | ALDH1A1 3583/4885POLB 686/4885MAPT 370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.