Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.36 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.35 |
| ▸ | ULK1 | O75385 | 1/20 | 0.35 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | UBE2M | P61081 | 1/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201272 | 0.89 | ULK1 (0.36) | SYKABCG2ULK1ULK2TRPV1 | |
| SCHEMBL22201286 | 0.87 | P2RX3 (0.40) | SYKPRKD1EGFRTGFBR1ALDH1A1 | |
| SCHEMBL22201327 | 0.86 | SYK (0.40) | SYKABCG2ULK1ULK2TRPV1 | |
| SCHEMBL22201368 | 0.86 | SYK (0.45) | SYKABCG2PRKD1TGFBR1ALDH1A1 | |
| SCHEMBL22201423 | 0.86 | TRPV1 (0.41) | ULK1ULK2TRPV1 | |
| SCHEMBL22201536 | 0.86 | ACP1 (0.36) | SYKPRKD1ULK1ULK2TGFBR1 | |
| SCHEMBL22201622 | 0.84 | SYK (0.42) | SYKULK1ULK2TRPV1 | |
| SCHEMBL22201326 | 0.83 | ULK1 (0.40) | ABCG2ULK1ULK2TSHRTRPV1 | |
| SCHEMBL22201273 | 0.83 | SYK (0.37) | SYKPRKD1TSHRTGFBR1ALDH1A1 | |
| SCHEMBL22201586 | 0.83 | PRKCH (0.47) | SYKABCG2TGFBR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |