Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.39 |
| ▸ | CDC42BPB | Q9Y5S2 | 8/20 | 0.39 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 4/20 | 0.36 |
| ▸ | BCR | P11274 | 4/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | PRKACG | P22612 | 1/20 | 0.36 |
| ▸ | PRKACB | P22694 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201403 | 0.90 | ROCK2 (0.35) | ROCK2ROCK1CDC42BPBABL1BCR | |
| SCHEMBL22201306 | 0.86 | SYK (0.41) | ROCK2ROCK1CDC42BPBHCRTR1P2RX3 | |
| SCHEMBL22201260 | 0.86 | ABL1 (0.39) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL22201287 | 0.86 | ABL1 (0.39) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL22201288 | 0.86 | ABL1 (0.39) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL22201267 | 0.84 | ABL1 (0.38) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL22201328 | 0.84 | ABL1 (0.38) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL22201277 | 0.84 | PRKCA (0.42) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL22201366 | 0.82 | MAPT (0.39) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL22201526 | 0.81 | ABL1 (0.35) | ABL1BCRSRCEGFRPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |