Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 6/20 | 0.38 |
| ▸ | SYK | P43405 | 6/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | PRKCH | P24723 | 1/20 | 0.35 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | IGF1R | P08069 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | TEK | Q02763 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201323 | 0.90 | SYK (0.38) | P2RX3SYKPRKCHPRKCECYP1A2 | |
| SCHEMBL22201421 | 0.90 | SYK (0.36) | P2RX3SYKADORA3PRKCHPRKCE | |
| SCHEMBL22201226 | 0.89 | PRKCH (0.37) | P2RX3SYKADORA3PRKCHPRKCE | |
| SCHEMBL22201366 | 0.89 | MAPT (0.39) | SYKCYP1A2EGFRSRC | |
| SCHEMBL22201327 | 0.87 | SYK (0.40) | SYKPRKCHPRKCEKDR | |
| SCHEMBL22201586 | 0.87 | PRKCH (0.47) | SYKPRKCHPRKCETGFBR1AURKB | |
| SCHEMBL22201224 | 0.87 | P2RX3 (0.42) | P2RX3SYKADORA3CYP1A2GRM4 | |
| SCHEMBL22201286 | 0.87 | P2RX3 (0.40) | P2RX3SYKADORA3KDREGFR | |
| SCHEMBL22201534 | 0.86 | PIK3CD (0.40) | SYKKDRTGFBR1AURKB | |
| SCHEMBL22201324 | 0.84 | ADORA3 (0.39) | P2RX3SYKADORA3PRKCHPRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |