Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | PIP4K2A | P48426 | 2/20 | 0.37 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.37 |
| ▸ | TYK2 | P29597 | 4/20 | 0.36 |
| ▸ | JAK3 | P52333 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 4/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | CD38 | P28907 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201262 | 0.88 | RIPK2 (0.36) | PIP4K2APIP4K2CTYK2JAK3JAK2 | |
| SCHEMBL22201366 | 0.87 | MAPT (0.39) | SYK | |
| SCHEMBL22201607 | 0.87 | RIPK2 (0.39) | PIP4K2APIP4K2CSYKRIPK2KDR | |
| SCHEMBL22201323 | 0.87 | SYK (0.38) | PIK3CGTYK2JAK3JAK2SYK | |
| SCHEMBL22201417 | 0.86 | P2RX3 (0.38) | SYKKDRAURKBTGFBR1 | |
| SCHEMBL22201421 | 0.86 | SYK (0.36) | SYKAURKBTGFBR1 | |
| SCHEMBL22201226 | 0.86 | PRKCH (0.37) | SYKAURKBKDM1ATGFBR1 | |
| SCHEMBL22201493 | 0.85 | ROCK2 (0.34) | PIK3CDPIK3CAPIK3CBPIK3CGSYK | |
| SCHEMBL22201322 | 0.84 | PIP4K2C (0.34) | PIK3CDPIK3CAPIK3CBPIK3CGPIP4K2A | |
| SCHEMBL22201586 | 0.84 | PRKCH (0.47) | SYKAURKBTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |