Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 7/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 3/20 | 0.31 |
| ▸ | CHUK | O15111 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201329 | 0.92 | P2RX3 (0.37) | P2RX3CYP11B1CYP11B2SYKLMNA | |
| SCHEMBL22201376 | 0.88 | SYK (0.39) | P2RX3SYKLMNA | |
| SCHEMBL22201564 | 0.86 | RIPK1 (0.36) | P2RX3SYKKDM4EMEN1KMT2A | |
| SCHEMBL22201401 | 0.83 | KDM4E (0.36) | P2RX3SYKKDM4EMEN1KMT2A | |
| SCHEMBL22201402 | 0.82 | MEN1 (0.36) | P2RX3SYKKDM4EMEN1KMT2A | |
| SCHEMBL22201404 | 0.82 | P2RX3 (0.38) | P2RX3KDM4EMEN1KMT2AROCK2 | |
| SCHEMBL22201565 | 0.81 | KDM4E (0.35) | P2RX3KDM4EMEN1KMT2AROCK2 | |
| SCHEMBL22201400 | 0.80 | KMT2A (0.37) | P2RX3SYKKDM4EMEN1KMT2A | |
| SCHEMBL22201399 | 0.80 | MEN1 (0.37) | P2RX3SYKKDM4EMEN1KMT2A | |
| SCHEMBL22201403 | 0.78 | ROCK2 (0.35) | P2RX3KDM4EMEN1KMT2AROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |